This title appears in the Scientific Report :
2001
Please use the identifier:
http://hdl.handle.net/2128/114 in citations.
Parallele Substratkontrolle in Bioreaktoren mit geringem Volumen
Parallele Substratkontrolle in Bioreaktoren mit geringem Volumen
In the first developmental phase of microbial processes, relevant parameters for reaction engineering are investigated and optimized with parallel experiments in small reactors (shake flask scale) . Substrate concentrations are central process parameters . Their control might help to increase effici...
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Personal Name(s): | Wolfram, Evelyn P. (Corresponding author) |
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Contributing Institute: |
Biotechnologie 2; IBT-2 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zenralbibliothek, Verlag
2002
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Physical Description: |
VII, 194 p. |
Dissertation Note: |
München, Techn. Univ., Diss., 2001 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
Verfahrenstechnik zur mikrobiellen Gewinnung von Primärmetaboliten |
Series Title: |
Berichte des Forschungszentrums Jülich
3982 |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
In the first developmental phase of microbial processes, relevant parameters for reaction engineering are investigated and optimized with parallel experiments in small reactors (shake flask scale) . Substrate concentrations are central process parameters . Their control might help to increase efficiency and quality of this developmental phase . Thus, a parallel, automatic and sterile sampling technique wich hollow fiber membranes was developed that suits the Small reaction volume. The parallel sampling modules were connected to a Substrate analysis system. The combination of the analytical technique with a controller and a precise microdosing System for Substrate closed the control loop. The prototype device was characterized and its suitability for online monitoring and control of bioprocesses confirmed . This technique allows for the firnt time online measurement and control of Substrate concentrations in parallel bioreactions (i.e . with Escherichia coli) wich measuring raten of the order of minutes |