This title appears in the Scientific Report :
1999
Please use the identifier:
http://hdl.handle.net/2128/3646 in citations.
Verteilung von Neurotransmitterrezeptoren in den Stammganglien des Menschen : eine quantitative autoradiographische Untersuchung
Verteilung von Neurotransmitterrezeptoren in den Stammganglien des Menschen : eine quantitative autoradiographische Untersuchung
Different neurotransmitter receptors in the human basal ganglia were analyzed with quantitative autoradiography. A major finding for all investigated receptors was the fact that the contrast between the two neurochemical compartments of the striatum decreases from dorsolateral to ventromedial. This...
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Personal Name(s): | Bauer, A. |
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Contributing Institute: |
Institut für Medizin; IME |
Imprint: |
Jülich
Forschungszentrum, Zentralbibliothek
1999
|
Dissertation Note: |
Düsseldorf, Univ., Diss., 1999 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
ohne FE |
Series Title: |
Berichte des Forschungszentrums Jülich
3633 |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
Different neurotransmitter receptors in the human basal ganglia were analyzed with quantitative autoradiography. A major finding for all investigated receptors was the fact that the contrast between the two neurochemical compartments of the striatum decreases from dorsolateral to ventromedial. This points to an additional principle of organization besides the compartmentalization of the striatum. GABAA receptors are differentially distributed in the associative and sensorimotor domains of the striatum. Higher receptor binding was found in the caudate nucleus. This result is in line with former findings of a more intensified local collateralization of the axons of the striate projection neurons and could indicate different modalities of signal processing in the associative and sensorimotor loops. Furthermore, GABAA receptors are distributed in a compartment specific manner, which may reflect different densities of GABAergic interneurons in matrix and striosomes The dopaminergic receptor subtypes are highly concentrated in the striosomal compartment. There are, however, significant differences between the different receptor subtypes in the matrix. D2 receptors are homogeneously distributed, whereas D1 receptors exhibit a characteristic biphasic distribution, with relatively high densities in the sensorimotor and limbic domains of the striatum. These results confirm the idea of an additional biochemical compartmentalization which is different from the striosome/matrix dichotomy. 5-Hydroxytryptamine primarily exerts its influence on the output nuclei of the basal ganglia. Furthermore, there are zones of different receptor densities within the substantia nigra which resemble those of the striosomes. In the cholinergic system receptor binding exhibits remarkable differences between extra- and intrastriosomal binding. This is probably an expression of the polarity of the cholinergic interneurons which are primarily located at the borders of the compartments. Furthermore, M2 receptors and D1 receptors are significantly colocalized. Thus, they seem to exert afference modulation synergistically |