This title appears in the Scientific Report :
2004
Comparison of O-(2-18F-fluoroethyl)-L-tyrosine PET and 3-123I-iodo-a-methyl-L-tyrosine SPECT in brain tumors
Comparison of O-(2-18F-fluoroethyl)-L-tyrosine PET and 3-123I-iodo-a-methyl-L-tyrosine SPECT in brain tumors
The aim of this study was to compare PET with O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) and SPECT with 3-I-123-iodo-alpha-methyl-L-tyrosine (I-123-IMT) in patients with brain tumors. Methods: Twenty patients with a suspected brain tumor were investigated by 18F-FET PET, I-123-IMT SPECT, and MRI w...
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Personal Name(s): | Pauleit, D. |
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Floeth, F. / Tellmann, L. / Hamacher, K. / Hautzel, H. / Müller, H. W. / Coenen, H. H. / Langen, K. J. | |
Contributing Institute: |
Institut für Medizin; IME Institut für Nuklearchemie; INC |
Published in: | Journal of nuclear medicine, 45 (2004) S. 374 - 381 |
Imprint: |
New York, NY
Society of Nuclear Medicine
2004
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Physical Description: |
374 - 381 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Journal of Nuclear Medicine
45 |
Subject (ZB): | |
Publikationsportal JuSER |
The aim of this study was to compare PET with O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) and SPECT with 3-I-123-iodo-alpha-methyl-L-tyrosine (I-123-IMT) in patients with brain tumors. Methods: Twenty patients with a suspected brain tumor were investigated by 18F-FET PET, I-123-IMT SPECT, and MRI within 3 wk. Region-of-interest analyses were performed on coregistered PET/ SPECT/MRI images and the tumor-to-brain ratio (TBR), muscle-to-brain ratio (MBR), cerebellum-to-brain ratio (CerBR), and sinus-to-brain ratio (SBR) were calculated. In addition, the presence of tumor and the discrimination of anatomic structures on 18F-FET PET and I-123-IMT SPECT images were visually determined by 3 observers who were unaware of clinical data. Results: The TBR of F-18-FET and I-123-IMT uptake in cerebral tumors showed a highly significant correlation (r = 0.96; P < 0.001). In the visual analysis for the presence or absence of tumors, no differences for I-123-IMT SPECT and F-18-FET PET were found in 19 of 20 patients; in one patient a low-grade glioma was only identified on 18F-FET PET images but not on I-123-IMT SPECT images. The contrast between tumor and normal brain was significantly higher in F-18-FET PET (TBR, 2.0 +/- 0.9) than in I-123-IMT SPECT (TBR, 1.5 +/- 0.5). The discrimination of anatomic structures yielded a significantly better score on 18F-FET PET images (rating score, 2.6 +/- 0.9) compared with I-123-IMT SPECT images (rating score, 1.7 +/- 0.9). The uptake of 18F-FET in the muscles was significantly higher compared with I-123-IMT (MBR F-18-FET, 1.4 +/- 0.3; MBR I-123-IMT, 0.6 +/- 0.2; P < 0.001) and F-18-FET demonstrated a significantly higher bloodpool radioactivity than I-123-IMT (SBR F-18-FET, 1.3 +/- 0.2; SBR I-123-IMT, 0.8 +/- 0.2; P < 0.001). Conclusion: The significant correlation of the TBRs of F-18-FET and I-123-IMT indicates that clinical experiences of brain tumor diagnostics with I-123-IMT SPECT might be valid for 18F-FET PET although substantial differences of the physiologic behavior were identified in extra-cerebral tissue. As F-18-FET PET allows improved discrimination of anatomic structures and the tumor-to-brain contrast was significantly superior compared with I-123-IMT SPECT scans, the results are encouraging for further evaluation of F-18-FET for imaging brain tumors. |