This title appears in the Scientific Report :
2005
Please use the identifier:
http://dx.doi.org/10.3171/jns.2005.102.2.0318 in citations.
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy
The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas.Both FET-PET and MR spectroscopy analyses were performed in 50 conse...
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Personal Name(s): | Floeth, F. |
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Pauleit, D. / Wittsack, H. J. / Langen, K. J. / Reifenberger, G. / Hamacher, K. / Messing-Jünger, M. / Zilles, K. / Weber, F. / Stummer, W. / Steiger, H. J. / Woebker, G. / Müller, H. W. / Coenen, H. H. / Sabel, M. | |
Contributing Institute: |
Institut für Medizin; IME Institut für Nuklearchemie; INC |
Published in: | Journal of neurosurgery, 102 (2005) S. 318 - 327 |
Imprint: |
Charlottesville, Va.
American Assoc. of Neurological Surgeons
2005
|
Physical Description: |
318 - 327 |
DOI: |
10.3171/jns.2005.102.2.0318 |
PubMed ID: |
15739561 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Journal of Neurosurgery
102 |
Subject (ZB): | |
Publikationsportal JuSER |
The purpose of this study was to determine the predictive value of [18F]fluoroethyl-L-tyrosine (FET)-positron emission tomography (PET) and magnetic resonance (MR) spectroscopy for tumor diagnosis in patients with suspected gliomas.Both FET-PET and MR spectroscopy analyses were performed in 50 consecutive patients with newly diagnosed intracerebral lesions supposed to be diffuse gliomas on contrast-enhanced MR imaging. Lesion/brain ratios of FET uptake greater than 1.6 were considered positive, that is, indicative of tumor. Results of MR spectroscopy were considered positive when N-acetylaspartate (NAA) was decreased in conjunction with an absolute increase of choline (Cho) and an NAA/Cho ratio of 0.7 or less. An FET lesion/brain ratio, an NAA/Cho ratio, and signal abnormalities on MR images were compared with histological findings in neuronavigated biopsy specimens. The FET lesion/brain ratio and the NAA/Cho ratio were identified as significant independent predictors for the histological identification of tumor tissue. The accuracy in distinguishing neoplastic from nonneoplastic tissue could be increased from 68% with the use of MR imaging alone to 97% with MR imaging in conjunction with FET-PET and MR spectroscopy. Sensitivity and specificity for tumor detection were 100 and 81% for MR spectroscopy and 88 and 88% for FET-PET, respectively. Results of histological studies did not reveal tumor tissue in any of the lesions that were negative on FET-PET and MR spectroscopy. In contrast, a tumor diagnosis was made in 97% of the lesions that were positive with both methods.In patients with intracerebral lesions supposed to be diffuse gliomas on MR imaging, FET-PET and MR spectroscopy analyses markedly improved the diagnostic efficacy of targeted biopsies. |