This title appears in the Scientific Report :
2005
18F-CPFPX PET identifies changes in cerebral A1 adenosine receptor density caused by glioma invasion
18F-CPFPX PET identifies changes in cerebral A1 adenosine receptor density caused by glioma invasion
Adenosine plays a critical role in both tumor proliferation and the cerebral response to tumor invasion. We used 8-cyclopentyl-tyl-3-(3-F-18-fluoropropyl)-1-propylxanthine (F-18-CPFPX) PET to investigate A, adenosine receptor (A(1)AR) density as a potential indicator of the local cerebral response t...
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Personal Name(s): | Bauer, A. |
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Langen, K. J. / Bidmon, H. / Holschbach, M. H. / Weber, S. / Olsson, R. A. / Coenen, H. H. / Zilles, K. | |
Contributing Institute: |
Institut für Medizin; IME Zentralinstitut für Elektronik; ZEL Institut für Nuklearchemie; INC |
Published in: | Journal of nuclear medicine, 46 (2005) S. 450 - 454 |
Imprint: |
New York, NY
Society of Nuclear Medicine
2005
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Physical Description: |
450 - 454 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Journal of Nuclear Medicine
46 |
Subject (ZB): | |
Publikationsportal JuSER |
Adenosine plays a critical role in both tumor proliferation and the cerebral response to tumor invasion. We used 8-cyclopentyl-tyl-3-(3-F-18-fluoropropyl)-1-propylxanthine (F-18-CPFPX) PET to investigate A, adenosine receptor (A(1)AR) density as a potential indicator of the local cerebral response to glioma invasion. Methods: A(1)AR density in F98 glioma-bearing rats was examined by F-18-CPFPX and H-3-CPFPX using PET, quantitative in vitro and ex vivo double-label receptor autoradiography, and immunohistochemical analyses. Results: For all imaging modalities, A1AR signal intensity was increased in a zone surrounding experimental tumors (136%-146% that in control tissue) (P < 0.01). Immunostaining identified activated astrocytes as the main origin of peritumoral A(1)AR upregulation. The results of a pilot F-18-CPFPX PET study on a patient with recurrent glioblastoma multiforme confirmed increases in AIAR density in the immediate vicinity of the tumor. Conclusion: F-18-CPFPX PET is suitable for the detection of peritumoral changes in A1AR density. Molecular imaging with F-18-CPFPX PET may open novel possibilities for gaining experimental and clinical insights into the cerebral response to tumor invasion. |