This title appears in the Scientific Report :
2005
Please use the identifier:
http://dx.doi.org/10.1016/j.apradiso.2004.09.009 in citations.
Labelling of manganese-based magnetic resonance imaging (MRI) contrast agents with the positron emitter 51Mn, as exemplified by manganese-tetraphenyl-porphin-sulfonate (MnTPPS4)
Labelling of manganese-based magnetic resonance imaging (MRI) contrast agents with the positron emitter 51Mn, as exemplified by manganese-tetraphenyl-porphin-sulfonate (MnTPPS4)
The potential tumor seeking MRI contrast agent MnTPPS(4) was labelled with the positron emitting nuclide (51)Mn in no-carrier-added (n.c.a.) form. The complex formation kinetics were investigated and the apparent rate constants were determined under pseudo-first-order conditions. The derived bimolec...
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Personal Name(s): | Klein, A. T. J. |
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Rösch, F. / Coenen, H. H. / Qaim, S. M. | |
Contributing Institute: |
Institut für Nuklearchemie; INC |
Published in: | Applied radiation and isotopes, 62 (2005) S. 711 - 720 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2005
|
Physical Description: |
711 - 720 |
PubMed ID: |
15763477 |
DOI: |
10.1016/j.apradiso.2004.09.009 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Applied Radiation and Isotopes
62 |
Subject (ZB): | |
Publikationsportal JuSER |
The potential tumor seeking MRI contrast agent MnTPPS(4) was labelled with the positron emitting nuclide (51)Mn in no-carrier-added (n.c.a.) form. The complex formation kinetics were investigated and the apparent rate constants were determined under pseudo-first-order conditions. The derived bimolecular rate constants gave the Arrhenius parameters E(A)=84 kJ mol(-1) and A=2 x 10(12)s(-1)M(-1). Optimum labelling conditions were derived (radiochemical yields >99% possible, effective yields about 32%). Separation and purification of n.c.a. (51)MnTPPS(4) were performed for potential human use. All impurities were <1%. |