This title appears in the Scientific Report :
2005
Please use the identifier:
http://dx.doi.org/10.1016/j.nucmedbio.2005.07.004 in citations.
Preferred stereoselective brain uptake of D-serine - a modulator of glutamatergic neurotransmission
Preferred stereoselective brain uptake of D-serine - a modulator of glutamatergic neurotransmission
Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-in...
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Personal Name(s): | Bauer, D. |
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Hamacher, K. / Bröer, S. / Pauleit, D. / Palm, C. / Zilles, K. / Coenen, H. H. / Langen, K. J. | |
Contributing Institute: |
Institut für Medizin; IME Institut für Nuklearchemie; INC |
Published in: | Nuclear medicine and biology, 32 (2005) S. 793 - 797 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2005
|
Physical Description: |
793 - 797 |
PubMed ID: |
16253803 |
DOI: |
10.1016/j.nucmedbio.2005.07.004 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Nuclear Medicine and Biology
32 |
Subject (ZB): | |
Publikationsportal JuSER |
Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of l-serine in the brain. Stimulated by the observation of a preferred transport of the d-isomer of proline at the blood-brain barrier, we investigated the differential uptake of [3H]-d-serine and [3H]-l-serine in the rat brain 1 h after intravenous injection using quantitative autoradiography. Surprisingly, brain uptake of [3H]-d-serine was significantly higher than that of [3H]-l-serine, indicating a preferred transport of the d-enantiomer of serine at the blood-brain barrier. This finding indicates that exogenous d-serine may have a direct influence on glutamatergic neurotransmission and associated diseases. |