This title appears in the Scientific Report :
2005
Please use the identifier:
http://hdl.handle.net/2128/2125 in citations.
Please use the identifier: http://dx.doi.org/10.1529/biophysj.105.061374 in citations.
Membrane on a Chip. A functional tethered lipid bilayer membrane on silicon oxide surface
Membrane on a Chip. A functional tethered lipid bilayer membrane on silicon oxide surface
Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the self-assembly of a thiolipid on ultrasmooth gold substrates, which shows extremely good electrical sealing pro...
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Personal Name(s): | Atanasov, V. |
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Knorr, N. / Duran, R. S. / Ingebrandt, S. / Offenhäusser, A. / Knoll, W. / Köper, I. | |
Contributing Institute: |
Center of Nanoelectronic Systems for Information Technology; CNI Institut für Bio- und Chemosensoren; ISG-2 |
Published in: | Biophysical journal, 89 (2005) S. 1780 - 1788 |
Imprint: |
New York, NY
Rockefeller Univ. Press
2005
|
Physical Description: |
1780 - 1788 |
DOI: |
10.1529/biophysj.105.061374 |
PubMed ID: |
16127170 |
Document Type: |
Journal Article |
Research Program: |
Materialien, Prozesse und Bauelemente für die Mikro- und Nanoelektronik |
Series Title: |
Biophysical Journal
89 |
Subject (ZB): | |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1529/biophysj.105.061374 in citations.
Tethered membranes have been proven during recent years to be a powerful and flexible biomimetic platform. We reported in a previous article on the design of a new architecture based on the self-assembly of a thiolipid on ultrasmooth gold substrates, which shows extremely good electrical sealing properties as well as functionality of a bilayer membrane. Here, we describe the synthesis of lipids for a more modular design and the adaptation of the linker part to silane chemistry. We were able to form a functional tethered bilayer lipid membrane with good electrical sealing properties covering a silicon oxide surface. We demonstrate the functional incorporation of the ion carrier valinomycin and of the ion channel gramicidin. |