This title appears in the Scientific Report :
2006
Please use the identifier:
http://dx.doi.org/10.1016/j.biopsych.2005.08.013 in citations.
Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study
Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study
Although there is evidence for attentional dysfunction in children with attention deficit/hyperactivity disorder (ADHD), the neural basis of these deficits remains poorly understood.We used event-related functional magnetic resonance imaging (fMRI) to investigate brain activations related to three p...
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Personal Name(s): | Konrad, K. |
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Neufang, S. / Hanisch, C. / Fink, G. R. / Herpertz-Dahlmann, B. | |
Contributing Institute: |
Institut für Medizin; IME JARA-BRAIN; JARA-BRAIN |
Published in: | Biological psychiatry, 59 (2006) S. 643 - 651 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2006
|
Physical Description: |
643 - 651 |
DOI: |
10.1016/j.biopsych.2005.08.013 |
PubMed ID: |
16197925 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Biological Psychiatry
59 |
Subject (ZB): | |
Publikationsportal JuSER |
Although there is evidence for attentional dysfunction in children with attention deficit/hyperactivity disorder (ADHD), the neural basis of these deficits remains poorly understood.We used event-related functional magnetic resonance imaging (fMRI) to investigate brain activations related to three particular aspects of attention: alerting, reorienting, and executive control. Sixteen medication-naive boys with ADHD and 16 healthy boys, aged 8 to 12 years, were studied.Behaviorally, children with ADHD showed a significant impairment only in their executive control system compared to healthy subjects. Neurally, children with ADHD (relative to controls) recruited deviant brain regions for all three attentional networks: less right-sided activation in the anterior cingulate gyrus during alerting, more fronto-striatal-insular activation during reorienting, and less fronto-striatal activation for executive control. ADHD symptom severity was associated with dysregulation of the blood oxygen level dependent (BOLD) signal within the putamen during reorienting and executive control.Our results demonstrated altered brain mechanism in ADHD associated with all three attentional networks investigated. For alerting and executive attention, our data indicate a deviant mechanism of cortical control, while ADHD children may have adopted altered strategies for reorienting of attention. Our results also stress the etiological role of functional abnormalities in the putamen in medication-naive ADHD. |