This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1063/1.2951987 in citations.
Please use the identifier: http://hdl.handle.net/2128/4643 in citations.
A simple patchy colloid model for the phase behavior of lysozyme dispersions
A simple patchy colloid model for the phase behavior of lysozyme dispersions
We propose a minimal model for spherical proteins with aeolotopic pair interactions to describe the equilibrium phase behavior of lysozyme. The repulsive screened Coulomb interactions between the particles are taken into account assuming that the net charges are smeared out homogeneously over the sp...
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Personal Name(s): | Gögelein, C. |
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Nägele, G. / Tuinier, R. / Gibaud, T. / Stradner, A. / Schurtenberger, P. | |
Contributing Institute: |
Weiche Materie; IFF-7 |
Published in: | The @journal of chemical physics, 129 (2008) S. 085102 |
Imprint: |
Melville, NY
American Institute of Physics
2008
|
Physical Description: |
085102 |
PubMed ID: |
19044852 |
DOI: |
10.1063/1.2951987 |
Document Type: |
Journal Article |
Research Program: |
Kondensierte Materie |
Series Title: |
Journal of Chemical Physics
129 |
Subject (ZB): | |
Link: |
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Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/4643 in citations.
We propose a minimal model for spherical proteins with aeolotopic pair interactions to describe the equilibrium phase behavior of lysozyme. The repulsive screened Coulomb interactions between the particles are taken into account assuming that the net charges are smeared out homogeneously over the spherical protein surfaces. We incorporate attractive surface patches, with the interactions between patches on different spheres modeled by an attractive Yukawa potential. The parameters entering the attractive Yukawa potential part are determined using information on the experimentally accessed gas-liquid-like critical point. The Helmholtz free energy of the fluid and solid phases is calculated using second-order thermodynamic perturbation theory. Our predictions for the solubility curve are in fair agreement with experimental data. In addition, we present new experimental data for the gas-liquid coexistence curves at various salt concentrations and compare these with our model calculations. In agreement with earlier findings, we observe that the strength and the range of the attractive potential part only weakly depend on the salt content. |