This title appears in the Scientific Report :
2006
18F-FET PET differentiation of ring-enhancing brain lesions
18F-FET PET differentiation of ring-enhancing brain lesions
The aim of this study was to explore the differential diagnostic value of PET using the amino acid O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) in patients with newly diagnosed solitary intracerebral lesions showing ring enhancement on contrast-enhanced MRI.Methods: F-18-FET PET analyses were perfor...
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Personal Name(s): | Floeth, F. W. |
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Pauleit, D. / Sabel, M. / Reifenberger, G. / Stoffels, G. / Stummer, W. / Rommel, F. / Hamacher, K. / Langen, K. J. | |
Contributing Institute: |
Institut für Medizin; IME Institut für Nuklearchemie; INC |
Published in: | Journal of nuclear medicine, 47 (2006) S. 776 - 782 |
Imprint: |
New York, NY
Society of Nuclear Medicine
2006
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Physical Description: |
776 - 782 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Nuclear Medicine
47 |
Subject (ZB): | |
Publikationsportal JuSER |
The aim of this study was to explore the differential diagnostic value of PET using the amino acid O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) in patients with newly diagnosed solitary intracerebral lesions showing ring enhancement on contrast-enhanced MRI.Methods: F-18-FET PET analyses were performed on 14 consecutive patients with intracerebral ring-enhancing lesions. Eleven of the patients were additionally studied with F-18-FDG PET. In all patients, the main differential diagnosis after MRI was a malignant lesion, in particular glioblastoma multiforme, versus a benign lesion, in particular brain abscess, A malignant tumor was suspected for lesions showing increased F-18-FET uptake on PET images with a mean lesion-to-brain ratio of at least 1.6 (F-18-FET PET positive). A nonneoplastic lesion was suspected in cases of minimal or absent F-18-FET uptake, with a mean lesion-to-brain ratio of less than 1.6 (F-18-FET PET negative) Histologic diagnosis was obtained by serial biopsies in 13 of the 14 patients. One patient refused the biopsy, but follow-up indicated an abscess because his lesion regressed under antibiotic therapy.Results: Histology and clinical follow-up showed high-grade malignant gliomas in 5 patients and nonneoplastic lesions in 9 patients. The findings of F-18-FET PET were positive in all 5 glioma patients and in 3 of 9 patients with nonneoplastic lesions, including 2 patients with brain abscesses and 1 patient with a demyelinating lesion. The findings of F-18-FDG PET were positive (mean lesion-to-gray matter ratio >= 0.7) in 4 of 4 glioma patients and 3 of 7 patients with nonneoplastic lesions.Conclusion: Although F-18-FET PET has been shown to be valuable for the diagnostic evaluation of brain tumors, our data indicate that, like 1(8F)-FDG PET, F-18-FET PET has limited specificity in distinguishing between neoplastic and nonneoplastic ring-enhancing intracerebral lesions. Thus, histologic investigation of biopsy specimens remains mandatory to make this important differential diagnosis. |