This title appears in the Scientific Report :
2006
Please use the identifier:
http://dx.doi.org/10.1111/j.1574-6968.2006.00456.x in citations.
Please use the identifier: http://hdl.handle.net/2128/596 in citations.
Evidence for activator and repressor functions of the response regulator MtrA from Corynebacterium glutamicum
Evidence for activator and repressor functions of the response regulator MtrA from Corynebacterium glutamicum
Previous analysis of a Corynebacterium glutamicum Delta mtrAB mutant showed that the MtrAB two-component signal transduction system influences the expression of genes involved in cell wall metabolism or osmoregulation, but it remained unknown whether this influence is direct or indirect. In order to...
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Personal Name(s): | Brocker, M. |
---|---|
Bott, M. | |
Contributing Institute: |
Biotechnologie 1; IBT-1 |
Published in: | FEMS microbiology letters, 264 (2006) S. 205 - 212 |
Imprint: |
Oxford [u.a.]
Wiley-Blackwell
2006
|
Physical Description: |
205 - 212 |
DOI: |
10.1111/j.1574-6968.2006.00456.x |
PubMed ID: |
17064374 |
Document Type: |
Journal Article |
Research Program: |
Biotechnologie |
Series Title: |
Fems Microbiology Letters
264 |
Subject (ZB): | |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/596 in citations.
Previous analysis of a Corynebacterium glutamicum Delta mtrAB mutant showed that the MtrAB two-component signal transduction system influences the expression of genes involved in cell wall metabolism or osmoregulation, but it remained unknown whether this influence is direct or indirect. In order to identify the direct target genes of the response regulator MtrA, chromatin immunoprecipitation as a genome-wide approach and DNA affinity chromatography as a gene-specific approach were used. The results indicate that mepA and nlpC, both encoding putative cell wall peptidases, are directly repressed by MtrA, whereas proP and betP, both encoding carriers for compatible solutes, are directly activated by MtrA. |