This title appears in the Scientific Report :
2006
Please use the identifier:
http://hdl.handle.net/2128/18341 in citations.
Please use the identifier: http://dx.doi.org/10.1524/zpch.2006.220.5.567 in citations.
Modern high resolution NMR for the study of structure, dynamics and interactions of biological macromolecules
Modern high resolution NMR for the study of structure, dynamics and interactions of biological macromolecules
High resolution liquid state nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for in vitro studies of structure and dynamics of soluble biological macromolecules under physiological conditions. The unique combination of atomically resolved structural data with both local and glo...
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Personal Name(s): | Stangler, T. |
---|---|
Hartmann, R. / Willbold, D. / Koenig, B. W. | |
Contributing Institute: |
Biologische Strukturforschung; IBI-2 Jülich-Aachen Research Alliance - Simulation Sciences; JARA-SIM |
Published in: | Zeitschrift für Physikalische Chemie, 220 (2006) S. 567 - 613 |
Imprint: |
München
Oldenbourg
2006
|
Physical Description: |
567 - 613 |
DOI: |
10.1524/zpch.2006.220.5.567 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Zeitschrift für physikalische Chemie
220 |
Subject (ZB): | |
Link: |
Get full text OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1524/zpch.2006.220.5.567 in citations.
High resolution liquid state nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for in vitro studies of structure and dynamics of soluble biological macromolecules under physiological conditions. The unique combination of atomically resolved structural data with both local and global dynamic features covering the entire range of time scales from picoseconds to seconds makes NMR the method of choice in a very diverse and rapidly growing array of biochemical, biomedical, and pharmaceutical applications. After briefly introducing the basic principles of liquid state NMR we review recent methodological and instrumental advances in the field of biologically focused high resolution NMR, The main emphasis of the second part is on molecular interactions. Such interactions are fundamental for the function of proteins in living systems, e.g. for signal transduction. enzymatic catalysis, and immune defense. The tremendous opportunities of high resolution NMR in the identification and detailed characterization of the sites and modes of molecular interactions will be demonstrated. |