This title appears in the Scientific Report :
2009
Please use the identifier:
http://dx.doi.org/10.1016/j.jbiotec.2009.04.007 in citations.
A game with many players: control of gdh transcription in Corynebacterium glutamicum
A game with many players: control of gdh transcription in Corynebacterium glutamicum
Glutamate dehydrogenase is a central enzyme connecting nitrogen and carbon metabolism via its precursors ammonium and oxoglutarate and its product glutamate. In Corynebacterium glutamicum glutamate dehydrogenase is especially important, since it is a key enzyme for the biotechnological production of...
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Personal Name(s): | Hänssler, E. |
---|---|
Müller, T. / Palumbo, K. / Patek, M. / Brocker, M. / Krämer, R. / Burkovski, A. | |
Contributing Institute: |
Biotechnologie 1; IBT-1 |
Published in: | Journal of biotechnology, 142 (2009) S. 114 - 122 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2009
|
Physical Description: |
114 - 122 |
PubMed ID: |
19394370 |
DOI: |
10.1016/j.jbiotec.2009.04.007 |
Document Type: |
Journal Article |
Research Program: |
Biotechnologie |
Series Title: |
Journal of Biotechnology
142 |
Subject (ZB): | |
Publikationsportal JuSER |
Glutamate dehydrogenase is a central enzyme connecting nitrogen and carbon metabolism via its precursors ammonium and oxoglutarate and its product glutamate. In Corynebacterium glutamicum glutamate dehydrogenase is especially important, since it is a key enzyme for the biotechnological production of the flavour enhancer L-glutamate. In this study, the regulation of gdh transcription was investigated. While originally described as a constitutively expressed gene, we could show that gdh transcription is highly variable depending on environmental conditions. Regulation of the gdh gene by the C. glutamicum nitrogen control protein AmtR was analyzed in detail in this study. |