This title appears in the Scientific Report :
2006
Please use the identifier:
http://dx.doi.org/10.1093/brain/aw1302 in citations.
Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease
Subthalamic stimulation modulates cortical control of urinary bladder in Parkinson's disease
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for off-period motor symptoms and dyskinesias in advanced Parkinson's disease. Clinical studies have shown that STN-DBS also ameliorates urinary bladder function in Parkinson's disease patients by delaying the fir...
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Personal Name(s): | Herzog, J. |
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Weiss, P. H. / Assmus, A. / Wefer, B. / Seif, C. / Braun, P. M. / Herzog, H. / Volkmann, J. / Deuschl, G. / Fink, G. R. | |
Contributing Institute: |
Institut für Medizin; IME |
Published in: | Brain, 129 (2006) S. 3366 - 3375 |
Imprint: |
Oxford
Oxford Univ. Press
2006
|
Physical Description: |
3366 - 3375 |
DOI: |
10.1093/brain/aw1302 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Brain
129 |
Subject (ZB): | |
Publikationsportal JuSER |
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective therapy for off-period motor symptoms and dyskinesias in advanced Parkinson's disease. Clinical studies have shown that STN-DBS also ameliorates urinary bladder function in Parkinson's disease patients by delaying the first desire to void and increasing bladder capacity. This study aimed at investigating the effect of STN-DBS on the neural mechanisms underlying cerebral bladder control. Using PET to measure changes in regional cerebral blood flow (rCBF), 11 patients with bilateral STN-DBS were studied during urodynamic bladder filling in STN-DBS ON and OFF condition. A filled bladder led to a significant increase of rCBF in the anterior cingulate cortex, which was further enhanced during STN-DBS OFF. A significant interaction between bladder state and STN-DBS was observed in lateral frontal cortex with increased rCBF when the bladder was filled during STN-DBS OFF. The data suggest that STN-DBS ameliorates bladder dysfunction and that this modulation may result from facilitated processing of afferent bladder information. |