This title appears in the Scientific Report :
2006
Please use the identifier:
http://dx.doi.org/10.1007/s00259-006-0178-3 in citations.
In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals
In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats.Fifteen male Lewis rats with different stages of renal dysfunctio...
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Personal Name(s): | Forrer, F. |
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Valkema, R. / Bernard, B. / Schramm, N. U. / Hoppin, J. W. / Rolleman, E. / Krenning, E. P. / de Jong, M. | |
Contributing Institute: |
Zentralinstitut für Elektronik; ZEL |
Published in: | European Journal of Nuclear Medicine and Molecular Imaging, 33 (2006) S. 1214 - 1217 |
Imprint: |
Heidelberg [u.a.]
Springer-Verl.
2006
|
Physical Description: |
1214 - 1217 |
DOI: |
10.1007/s00259-006-0178-3 |
PubMed ID: |
16832630 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
European Journal of Nuclear Medicine and Molecular Imaging
33 |
Subject (ZB): | |
Publikationsportal JuSER |
In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats.Fifteen male Lewis rats with different stages of renal dysfunction were injected with 50 MBq 99mTc-dimercaptosuccinic acid. Four to six hours after injection, SPECT of the kidneys was acquired with a new four-headed multi-pinhole collimator camera. Immediately after imaging the rats were sacrificed and the kidneys were counted in a gamma-counter to determine the absorbed activity. SPECT data were reconstructed iteratively and regions of interest (ROIs) were drawn manually. The absolute activity in the ROIs was determined.Uptake values ranging from 0.71% to 21.87% of the injected activity were measured. A very strong linear correlation was found between the determined activity in vivo and ex vivo (r2=0.946; slope m=1.059).Quantification in vivo using this multi-pinhole SPECT system is highly accurate. |