This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1016/j.ijms.2008.01.001 in citations.
Monitoring of platinum in a single hair by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) after cisplatin treatment for cancer
Monitoring of platinum in a single hair by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) after cisplatin treatment for cancer
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to quantify and monitor the concentration of Pt along a single strand of hair from a patient who had been treated with cisplatin as cytostatic drug. The sensitivity of the analytical method developed could be increased...
Saved in:
Personal Name(s): | Pozebon, D. |
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Dressler, V. L. / Matusch, A. / Becker, J. S. | |
Contributing Institute: |
Zentralabteilung für Chemische Analysen; ZCH |
Published in: | International journal of mass spectrometry, 272 (2008) S. 57 - 62 |
Imprint: |
[S.l.]
Elsevier Science
2008
|
Physical Description: |
57 - 62 |
DOI: |
10.1016/j.ijms.2008.01.001 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
International Journal of Mass Spectrometry
272 |
Subject (ZB): | |
Publikationsportal JuSER |
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to quantify and monitor the concentration of Pt along a single strand of hair from a patient who had been treated with cisplatin as cytostatic drug. The sensitivity of the analytical method developed could be increased by total ablation of the hair cross-section compared to partial ablation. A low-noise intensity ratio was obtained along the strand, while the blank was negligible. The variation of the Pt signal with reference to each cisplatin dose was clearly observed. Home-made standards consisting of Pt-enriched hair strands served as calibrators and sulphur (measuring S-34(+)) was used as the internal reference element. The correlation coefficient of the calibration curve for platinum was 0.9973 and the detection limit was 0.029 mu g g(-1). The rate of hair growth between doses was constant. The mean relative standard deviation (R.S.D.) for five replicates of single hair strands ranged from 15 to 22%. The maximum concentrations of Pt found along the hair strands were 26.9 +/- 5.3, 14.7 +/- 3.3, 20.9 +/- 3.9 and 26.1 +/- 3.8 mu g g(-1), which correspond to four treatment of cisplatin administered to the patient at 3-week intervals. (c) 2008 Elsevier B.V. All rights reserved. |