This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.2967/jnumed.108.050880 in citations.
Comparison of 99mTc and 18F-ubiquicidin autoradiography to anti-staphylococcus aureus immunfluorescence in rat muscle abscesses
Comparison of 99mTc and 18F-ubiquicidin autoradiography to anti-staphylococcus aureus immunfluorescence in rat muscle abscesses
99mTc-ubiquicidin (UBI) 29-41 is under clinical evaluation for discrimination between bacterial infection and unspecific inflammation. We compared the distribution of 99mTc-UBI 29-41, the potential PET tracers 18F-UBI 29-41 and 18F-UBI 28-41, and 3H-deoxyglucose (DG) in rat muscle abscesses to that...
Saved in:
Personal Name(s): | Salber, D. |
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Gunawan, J. / Langen, K. J. / Fricke, E. / Klauth, P. / Burchert, W. / Zijlstra, S. | |
Contributing Institute: |
Institut für Neurowissenschaften und Biophysik - Medizin; INB-3 |
Published in: | Journal of Nuclear Medicine Journal of nuclear medicine, 49 49 (2008 2008) 6 6, S. 995-999 995-999 |
Imprint: |
New York, NY
Society of Nuclear Medicine
2008
2008-05-15 |
Physical Description: |
995 - 999 |
DOI: |
10.2967/jnumed.108.050880 |
PubMed ID: |
18483088 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Nuclear Medicine
49 |
Subject (ZB): | |
Publikationsportal JuSER |
99mTc-ubiquicidin (UBI) 29-41 is under clinical evaluation for discrimination between bacterial infection and unspecific inflammation. We compared the distribution of 99mTc-UBI 29-41, the potential PET tracers 18F-UBI 29-41 and 18F-UBI 28-41, and 3H-deoxyglucose (DG) in rat muscle abscesses to that of anti-Staphylococcus aureus immunofluorescent imaging.Calf abscesses were induced in 15 CDF-Fischer rats after inoculation of Staphylococcus aureus. One to 6 d later, either 18F-UBI 29-41 and 3H-DG (n = 5) or 18F-UBI 28-41 and 3H-DG (n = 6) or 99mTc-UBI 29-41 and 3H-DG (n = 4) were injected simultaneously. Dual-tracer autoradiography of the abscess area was compared with the distribution of bacteria and macrophages.The UBI derivates exhibited increased uptake in the abscess area that partly matched 3H-DG uptake and macrophage infiltration but showed no congruity with areas that were highly positive for bacteria.A specific binding of UBI derivatives to Staphylococcus aureus in vivo could not be confirmed in this study. |