This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1007/s00259-008-0734-0 in citations.
MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data
MR-based attenuation correction for torso-PET/MR imaging: pitfalls in mapping MR to CT data
MR-based attenuation correction (AC) will become an integral part of combined PET/MR systems. Here, we propose a toolbox to validate MR-AC of clinical PET/MRI data sets.Torso scans of ten patients were acquired on a combined PET/CT and on a 1.5-T MRI system. MR-based attenuation data were derived fr...
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Personal Name(s): | Beyer, T. |
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Weigert, M. / Quick, H. H. / Pietrzyk, U. / Vogt, F. / Palm, C. / Antoch, G. / Müller, S. P. / Bockisch, A. | |
Contributing Institute: |
Institut für Neurowissenschaften und Biophysik - Medizin; INB-3 |
Published in: | European Journal of Nuclear Medicine and Molecular Imaging, 35 (2008) S. 1142 - 1146 |
Imprint: |
Heidelberg [u.a.]
Springer-Verl.
2008
|
Physical Description: |
1142 - 1146 |
DOI: |
10.1007/s00259-008-0734-0 |
PubMed ID: |
18283452 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
European Journal of Nuclear Medicine and Molecular Imaging
35 |
Subject (ZB): | |
Publikationsportal JuSER |
MR-based attenuation correction (AC) will become an integral part of combined PET/MR systems. Here, we propose a toolbox to validate MR-AC of clinical PET/MRI data sets.Torso scans of ten patients were acquired on a combined PET/CT and on a 1.5-T MRI system. MR-based attenuation data were derived from the CT following MR-CT image co-registration and subsequent histogram matching. PET images were reconstructed after CT- (PET(CT)) and MR-based AC (PET(MRI)). Lesion-to-background (L/B) ratios were estimated on PET(CT) and PET(MRI).MR-CT histogram matching leads to a mean voxel intensity difference in the CT- and MR-based attenuation images of 12% (max). Mean differences between PET(MRI) and PET(CT) were 19% (max). L/B ratios were similar except for the lung where local misregistration and intensity transformation leads to a biased PET(MRI).Our toolbox can be used to study pitfalls in MR-AC. We found that co-registration accuracy and pixel value transformation determine the accuracy of PET(MRI). |