This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1089/rej.2008.0670 in citations.
An Ultra-Sensitive Assay For Diagnosis Of Alzheimer's Disease
An Ultra-Sensitive Assay For Diagnosis Of Alzheimer's Disease
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certainty only post mortem, detecting insoluble beta-amyloid peptide (Abeta) aggregates in the patient's...
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Personal Name(s): | Funke, S. A. |
---|---|
Birkmann, E. / Henke, F. / Görtz, P. / Lange-Asschenfeldt, C. / Riesner, D. / Willbold, D. | |
Contributing Institute: |
Molekulare Biophysik; INB-2 |
Published in: | Rejuvenation research, 11 (2008) S. 315 - 318 |
Imprint: |
Larchmont, NY
Liebert
2008
|
Physical Description: |
315 - 318 |
DOI: |
10.1089/rej.2008.0670 |
PubMed ID: |
18328004 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Rejuvenation Research
11 |
Subject (ZB): | |
Publikationsportal JuSER |
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and the most common cause of dementia. Aging is among the most significant risk factors. Today, AD can be diagnosed with certainty only post mortem, detecting insoluble beta-amyloid peptide (Abeta) aggregates in the patient's brain tissue. We have developed an ultrasensitive assay for early and non-invasive diagnosis of AD. This highly specific and sensitive assay uses fluorescence correlation spectroscopy (FCS) and is sensitive enough to detect even single aggregates in body fluids of AD patients. We investigate the correlation of aggregated Abeta concentrations in body fluids with clinical symptoms of AD. |