This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.2217/fon.15.334 in citations.
Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients
Prediction of radiation-induced toxicity by in vitro radiosensitivity of lymphocytes in prostate cancer patients
Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients.Patients & methods: Patients have been surveyed prospectively before and up to 16 monthsafter radiotherapy using a validated questionnaire. Subgroups of 25 patients with minorand larger score changes, r...
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Personal Name(s): | Pinkawa, Michael (Corresponding author) |
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Brzozowska, Kinga / Kriehuber, Ralf / Eble, Michael J / Schmitz, Sabine | |
Contributing Institute: |
Sicherheit und Strahlenschutz, Umgebungsüberwachung,Strahlenbiologie; S-US |
Published in: | Future oncology, 12 (2016) 5, S. 617 - 624 |
Imprint: |
London
Future Medicine Ltd
2016
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DOI: |
10.2217/fon.15.334 |
Document Type: |
Journal Article |
Research Program: |
ohne Topic |
Subject (ZB): | |
Publikationsportal JuSER |
Aim: To identify predictive assays for radiation-induced toxicity in prostate cancer patients.Patients & methods: Patients have been surveyed prospectively before and up to 16 monthsafter radiotherapy using a validated questionnaire. Subgroups of 25 patients with minorand larger score changes, respectively, were selected for γ-H2AX, G2 and Annexin V assays.Results: A significantly higher spontaneous chromatid aberration yield (HR: 1.46 [95% CI:1.02–2.09]; p = 0.04), higher levels of early apoptotic (HR: 1.12 [95% CI: 1.01–1.24]; p = 0.04) andlate apoptotic and necrotic (HR: 1.10 [95% CI: 0.99–1.23]; p = 0.08) lymphocytes 24-h postirradiationwere found in patients with a bowel bother score decrease greater than 20 pointsmore than 1 year after treatment. Conclusion: Chromatid aberration and apoptosis/necrosisassays appear to be suitable for the prediction of radiation-induced toxicity. |