This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1039/C5DT04270D in citations.
Radiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging
Radiolabelling with isotopic mixtures of $^{52g/55}$Mn(II) as a straight route to stable manganese complexes for bimodal PET/MR imaging
Radiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-add...
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Personal Name(s): | Vanasschen, Christian (Corresponding author) |
---|---|
Brandt, Marie / Ermert, Johannes / Coenen, Heinrich Hubert | |
Contributing Institute: |
Nuklearchemie; INM-5 |
Published in: | Dalton transactions, 45 (2016) 4, S. 1315–1321 |
Imprint: |
London
The Royal Society of Chemistry
2016
|
PubMed ID: |
26685974 |
DOI: |
10.1039/C5DT04270D |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
Radiolabelling using isotopic mixtures of 52g/55Mn(ii) offers fast and easy access to new small molecule PET/MR tracers, composed of chemically identical reporting units. trans-1,2-Diaminocyclohexane-N,N,N[prime or minute],N[prime or minute]-tetraacetic acid (CDTA) was radiolabelled with carrier-added 52gMn(ii) in >99% radiochemical yield, producing the first manganese-based bimodal PET/MR probe. The Mn-CDTA chelate was shown to be very stable to air oxidation and sufficiently inert to decomplexation in blood serum. These data sparked our interest in functionalized CDTA ligands for the design of optimized PET/MR tracers. |