This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1016/j.bpj.2015.11.628 in citations.
Gating charge calculations: Probing voltage-sensing proteins through computational electrophysiology
Gating charge calculations: Probing voltage-sensing proteins through computational electrophysiology
Sensitivity to voltage stimuli is a defining property of electrical excitability and is found in ion channels with dedicated voltage sensors, but also in other channels, transporters and even metabotropic receptors. Voltage dependence is conferred by an effective transmembrane charge transfer that c...
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Personal Name(s): | Machtens, Jan-Philipp (Corresponding author) |
---|---|
Briones, R. / de Groot, B. L. / Fahlke, Christoph | |
Contributing Institute: |
Zelluläre Biophysik; ICS-4 |
Published in: | Biophysical journal, 110 (2016) 3, S. 106A |
Imprint: |
Cambridge, Mass.
Cell Press
2016
|
Physical Description: |
106A |
DOI: |
10.1016/j.bpj.2015.11.628 |
Conference: | 60th Annual Meeting of the Biophysical-Society, Los Angeles, CA (USA), 2016-02-27 - 2016-03-02 |
Document Type: |
Contribution to a conference proceedings Journal Article |
Research Program: |
Physical Basis of Diseases |
Publikationsportal JuSER |
Sensitivity to voltage stimuli is a defining property of electrical excitability and is found in ion channels with dedicated voltage sensors, but also in other channels, transporters and even metabotropic receptors. Voltage dependence is conferred by an effective transmembrane charge transfer that can be attributed to global or localized conformational changes, ion or ligand binding, protonation or changes in water accessibility that reshape the electric field. |