This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1016/j.bbamem.2016.07.002 in citations.
Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide
Blood-brain barrier penetration of an Aβ-targeted, arginine-rich, d-enantiomeric peptide
The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid residues obtained from mirror-image phage display...
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Personal Name(s): | Jiang, Nan |
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Frenzel, Daniel / Schartmann, Elena / van Groen, Thomas / Kadish, Inga / Shah, N. J. / Langen, Karl-Josef / Willbold, Dieter (Corresponding author) / Willuweit, Antje | |
Contributing Institute: |
Physik der Medizinischen Bildgebung; INM-4 JARA-BRAIN; JARA-BRAIN Strukturbiochemie; ICS-6 |
Published in: | Biochimica et biophysica acta / Biomembranes, 1858 (2016) 11, S. 2717 - 2724 |
Imprint: |
Amsterdam
Elsevier
2016
|
DOI: |
10.1016/j.bbamem.2016.07.002 |
PubMed ID: |
27423267 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
The application of small peptides targeting amyloid beta (Aβ) is one of many drug development strategies for the treatment of Alzheimer's disease (AD). We have previously identified several peptides consisting solely of D-enantiomeric amino acid residues obtained from mirror-image phage display selection, which bind to Aβ in different assembly states and eliminate toxic Aβ aggregates. Some of these D-peptides show both diagnostic and therapeutic potential in vitro and in vivo. Here we have analysed the similarity of the arginine-rich D-peptide D3 to the arginine-rich motif (ARM) of the human immunodeficiency virus type 1 transactivator of transcription (HIV-Tat) protein, and examined its in vivo blood-brain barrier (BBB) permeability using wild type mice and transgenic mouse models of Alzheimer's disease. We are able to demonstrate that D3 rapidly enters the brain where it can be found associated with amyloid plaques suggesting a direct penetration of BBB. |