This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1523/JNEUROSCI.4375-15.2016 in citations.
Please use the identifier: http://hdl.handle.net/2128/12258 in citations.
Synchronous Spike Patterns in Macaque Motor Cortex during an Instructed-Delay Reach-to-Grasp Task
Synchronous Spike Patterns in Macaque Motor Cortex during an Instructed-Delay Reach-to-Grasp Task
The computational role of spike time synchronization at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological te...
Saved in:
Personal Name(s): | Torre, E. |
---|---|
Quaglio, P. / Denker, M. / Brochier, T. / Riehle, A. / Grun, S. (Corresponding author) | |
Contributing Institute: |
Computational and Systems Neuroscience; INM-6 Computational and Systems Neuroscience; IAS-6 |
Published in: | Journal of Neuroscience The journal of neuroscience, 36 36 (2016 2016) 32 32, S. 8329-8340 8329-8340 |
Imprint: |
Washington, DC
Soc.69657
2016
2016-08-10 2016-08-10 2016-08-10 |
DOI: |
10.1523/JNEUROSCI.4375-15.2016 |
PubMed ID: |
27511007 |
Document Type: |
Journal Article |
Research Program: |
The Human Brain Project Brain-inspired multiscale computation in neuromorphic hybrid systems Connectivity and Activity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/12258 in citations.
The computational role of spike time synchronization at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological technology to record from hundreds of neurons simultaneously provide the opportunity to observe coordinated spiking activity of larger populations of cells. We recently published a method that combines data mining and statistical evaluation to search for significant patterns of synchronous spikes in massively parallel spike trains (Torre et al., 2013). The method solves the computational and multiple testing problems raised by the high dimensionality of the data. In the current study, we used our method on simultaneous recordings from two macaque monkeys engaged in an instructed-delay reach-to-grasp task to determine the emergence of spike synchronization in relation to behavior. We found a multitude of synchronous spike patterns aligned in both monkeys along a preferential mediolateral orientation in brain space. The occurrence of the patterns is highly specific to behavior, indicating that different behaviors are associated with the synchronization of different groups of neurons (“cell assemblies”). However, pooled patterns that overlap in neuronal composition exhibit no specificity, suggesting that exclusive cell assemblies become active during different behaviors, but can recruit partly identical neurons. These findings are consistent across multiple recording sessions analyzed across the two monkeys. |