This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1007/s00259-016-3360-2 in citations.
Diagnostic potential of PET/CT using a $^{68}$Ga-labelled prostate-specific membrane antigen ligand in whole-body staging of renal cell carcinoma: initial experience
Diagnostic potential of PET/CT using a $^{68}$Ga-labelled prostate-specific membrane antigen ligand in whole-body staging of renal cell carcinoma: initial experience
Purpose To evaluate the diagnostic potential of whole-bodyPET/CT using a 68Ga-labelled PSMA ligand in renal cell carcinoma(RCC).Methods Six patients with histopathologically proven RCCunderwent 68Ga-PSMA PET/CT. Each PET/CT scan wasevaluated in relation to lesion count, location and dignity.SUVmax w...
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Personal Name(s): | Sawicki, Lino M. (Corresponding author) |
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Buchbender, Christian / Boos, Johannes / Giessing, Markus / Ermert, Johannes / Antke, Christina / Antoch, Gerald / Hautzel, Hubertus | |
Contributing Institute: |
Klinisch-Medizinische Einrichtungen (Univ. Düsseldorf); KME Nuklearchemie; INM-5 |
Published in: | European journal of nuclear medicine and molecular imaging, 44 (2017) 1, S. 102 - 107 |
Imprint: |
Heidelberg [u.a.]
Springer-Verl.
2017
|
PubMed ID: |
26996777 |
DOI: |
10.1007/s00259-016-3360-2 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Publikationsportal JuSER |
Purpose To evaluate the diagnostic potential of whole-bodyPET/CT using a 68Ga-labelled PSMA ligand in renal cell carcinoma(RCC).Methods Six patients with histopathologically proven RCCunderwent 68Ga-PSMA PET/CT. Each PET/CT scan wasevaluated in relation to lesion count, location and dignity.SUVmax was measured in primary tumours and PETpositivemetastases. Tumour-to-background SUVmax ratios(TBRSUVmax) were calculated for primary RCCs in relationto the surrounding normal renal parenchyma. Metastasis-tobackgroundSUVmax ratios (MBRSUVmax) were calculatedfor PET-positive metastases in relation to gluteal muscle.Results Five primary RCCs and 16 metastases were evaluated.The mean SUVmax of the primary RCCs was 9.9 ± 9.2(range 1.7 – 27.2). Due to high uptake in the surrounding renalparenchyma, the mean TBRSUVmax of the primary RCCs wasonly 0.2 ± 0.3 (range 0.02 – 0.7). Eight metastases showed focal68Ga-PSMA uptake (SUVmax 9.9 ± 8.3, range 3.4 – 25.6).The mean MBRSUVmax of these PET-positive metastases was11.7 ± 0.2 (range 4.4 – 28.1). All PET-negative metastaseswere subcentimetre lung metastases.Conclusion 68Ga-PSMA PET/CT appears to be a promisingmethod for detecting RCC metastases. However, no additionaldiagnostic value in assessing the primary tumour was found. |