This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1016/j.apradiso.2016.04.030 in citations.
Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions
Automated synthesis of 4-[$^{18}$F]fluoroanisole, [$^{18}$F]DAA1106 and 4-[$^{18}$F]FPhe using Cu-mediated radiofluorination under “minimalist” conditions
The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabl...
Saved in:
Personal Name(s): | Zischler, Johannes |
---|---|
Krapf, Philipp / Richarz, Raphael / Zlatopolskiy, Boris D. / Neumaier, Bernd (Corresponding author) | |
Contributing Institute: |
Nuklearchemie; INM-5 |
Published in: | Applied radiation and isotopes, 115 (2016) S. 133 - 137 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2016
|
DOI: |
10.1016/j.apradiso.2016.04.030 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
The application of the “minimalist” approach to Cu-mediated radiofluorination allows the efficient preparation of 18F-labeled arenes regardless of their electronic properties. The implementation of this methodology on a commercially available synthesis module (hotboxthree, Scintomics, Germany) enabled the automated production of 4-[18F]fluoroanisole as well as the clinically relevant PET-tracers, 4-[18F]FPhe and [18F]DAA1106, in radiochemical yields of 41–61% and radiochemical purities of >95% within 30–60 min. These results demonstrated the high efficacy and versatility of the developed method that will open up opportunities for a broad application of Cu-mediated radiofluorination in PET-chemistry. |