This title appears in the Scientific Report :
2016
Please use the identifier:
http://dx.doi.org/10.1021/acsami.6b04449 in citations.
Simple and Flexible Model for Laser-Driven Antibody–Gold Surface Interactions: Functionalization and Sensing
Simple and Flexible Model for Laser-Driven Antibody–Gold Surface Interactions: Functionalization and Sensing
Interactions between biomolecules and between substrates and biomolecules is a crucial issue in physics and applications to topics such as biotechnology and organic electronics. The efficiency of bio- and mechanical sensors, of organic electronics systems, and of a number of other devices critically...
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Personal Name(s): | Della Ventura, Bartolomeo |
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Ambrosio, Antonio / Fierro, Annalisa / Funari, Riccardo / Gesuele, Felice / Maddalena, Pasquale / Mayer, Dirk / Pica Ciamarra, Massimo (Corresponding author) / Velotta, Raffaele / Altucci, Carlo (Corresponding author) | |
Contributing Institute: |
JARA-FIT; JARA-FIT Bioelektronik; PGI-8 |
Published in: | ACS applied materials & interfaces, 8 (2016) 33, S. 21762 - 21769 |
Imprint: |
Washington, DC
Soc.
2016
|
DOI: |
10.1021/acsami.6b04449 |
Document Type: |
Journal Article |
Research Program: |
Controlling Configuration-Based Phenomena |
Publikationsportal JuSER |
Interactions between biomolecules and between substrates and biomolecules is a crucial issue in physics and applications to topics such as biotechnology and organic electronics. The efficiency of bio- and mechanical sensors, of organic electronics systems, and of a number of other devices critically depends on how molecules are deposited on a surface so that these acquire specific functions. Here, we tackle this vast problem by developing a coarse grained model of biomolecules having a recognition function, such as antibodies, capable to quantitatively describe in a simple manner essential phenomena: antigen–antibody and antibody substrate interactions. The model is experimentally tested to reproduce the results of a benchmark case, such as (1) gold surface functionalization with antibodies and (2) antibody–antigen immune-recognition function. The agreement between experiments and model prediction is excellent, thus unveiling the mechanism for antibody immobilization onto metals at the nanoscale in various functionalization schemes. These results shed light on the geometrical packing properties of the deposited molecules, and may open the way to a novel coarse-grained based approach to describe other processes where molecular packing is a key issue with applications in a huge number of fields from nano- to biosciences. |