This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1093/neuonc/now149 in citations.
Dynamic O -(2-$^{18}$ F-fluoroethyl)-L-tyrosine positron emission tomography differentiates brain metastasis recurrence from radiation injury after radiotherapy
Dynamic O -(2-$^{18}$ F-fluoroethyl)-L-tyrosine positron emission tomography differentiates brain metastasis recurrence from radiation injury after radiotherapy
BackgroundThe aim of this study was to investigate the potential of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET for differentiating local recurrent brain metastasis from radiation injury after radiotherapy since contrast-enhanced MRI often remains inconclusive.MethodsSixty-two patients (...
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Personal Name(s): | Ceccon, Garry |
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Lohmann, Philipp / Stoffels, Gabriele / Judov, Natalie / Filss, Christian / Rapp, Marion / Bauer, Elena / Hamisch, Christina / Ruge, Maximilian I. / Kocher, Martin / Kuchelmeister, Klaus / Sellhaus, Bernd / Sabel, Michael / Fink, Gereon R. / Shah, Nadim J. / Langen, Karl-Josef / Galldiks, Norbert (Corresponding author) | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 JARA-BRAIN; JARA-BRAIN Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Neuro-Oncology, 19 (2017) 2, S. 281-288 |
Imprint: |
Oxford
Oxford Univ. Press
2017
|
PubMed ID: |
27471107 |
DOI: |
10.1093/neuonc/now149 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
BackgroundThe aim of this study was to investigate the potential of dynamic O-(2-[18F]fluoroethyl)-L-tyrosine (18F-FET) PET for differentiating local recurrent brain metastasis from radiation injury after radiotherapy since contrast-enhanced MRI often remains inconclusive.MethodsSixty-two patients (mean age, 55 ± 11 y) with single or multiple contrast-enhancing brain lesions (n = 76) on MRI after radiotherapy of brain metastases (predominantly stereotactic radiosurgery) were investigated with dynamic 18F-FET PET. Maximum and mean tumor-to-brain ratios (TBRmax, TBRmean) of 18F-FET uptake were determined (20–40 min postinjection) as well as tracer uptake kinetics (ie, time-to-peak and slope of time-activity curves). Diagnoses were confirmed histologically (34%; 26 lesions in 25 patients) or by clinical follow-up (66%; 50 lesions in 37 patients). Diagnostic accuracies of PET parameters for the correct identification of recurrent brain metastasis were evaluated by receiver-operating-characteristic analyses or the chi-square test.ResultsTBRs were significantly higher in recurrent metastases (n = 36) than in radiation injuries (n = 40) (TBRmax 3.3 ± 1.0 vs 2.2 ± 0.4, P < .001; TBRmean 2.2 ± 0.4 vs 1.7 ± 0.3, P < .001). The highest accuracy (88%) for diagnosing local recurrent metastasis could be obtained with TBRs in combination with the slope of time-activity curves (P < .001).ConclusionsThe results of this study confirm previous preliminary observations that the combined evaluation of the TBRs of 18F-FET uptake and the slope of time-activity curves can differentiate local brain metastasis recurrence from radiation-induced changes with high accuracy. 18F-FET PET may thus contribute significantly to the management of patients with brain metastases. |