This title appears in the Scientific Report :
2016
Please use the identifier:
http://hdl.handle.net/2128/13399 in citations.
Please use the identifier: http://dx.doi.org/10.1002/acn3.339 in citations.
Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease.
In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer...
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Personal Name(s): | Bischof, Gérard N. (Corresponding author) |
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Jessen, Frank / Fliessbach, Klaus / Dronse, Julian / Hammes, Jochen / Neumaier, Bernd / Onur, Oezguer / Fink, Gereon R. / Kukolja, Juraj / Drzezga, Alexander / van Eimeren, Thilo | |
Contributing Institute: |
Nuklearchemie; INM-5 Kognitive Neurowissenschaften; INM-3 |
Published in: | Annals of Clinical and Translational Neurology, 3 (2016) 12, S. 934 - 939 |
Imprint: |
Chichester [u.a.]
Wiley
2016
|
PubMed ID: |
28097205 |
DOI: |
10.1002/acn3.339 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1002/acn3.339 in citations.
In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary tangles (measured with [18F]AV-1451) and beta-amyloid burden (measured with [11C]PiB) on degree of neurodegeneration (i.e., glucose metabolism measured with [18F]FDG-PET) in patients with Alzheimer's disease. Across brain regions, we observed an interactive effect of beta-amyloid burden and tau deposition on glucose metabolism which was most pronounced in the parietal lobe. Elevated beta-amyloid burden was associated with a stronger influence of tau accumulation on glucose metabolism. Our data provide the first in vivo insights into the differential contribution of Aβ and tau to neurodegeneration in Alzheimer's disease. |