This title appears in the Scientific Report :
2018
Please use the identifier:
http://hdl.handle.net/2128/17740 in citations.
Please use the identifier: http://dx.doi.org/10.1016/j.neuroimage.2017.02.034 in citations.
The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
The heterogeneity of the left dorsal premotor cortex evidenced by multimodal connectivity-based parcellation and functional characterization
Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro...
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Personal Name(s): | GENON, Sarah (Corresponding author) |
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Reid, Andrew / Li, Hai / Fan, Lingzhong / Müller, Veronika / Cieslik, Edna / Hoffstaedter, Felix / Langner, Robert / Grefkes, Christian / Laird, Angela R. / Fox, Peter T. / Jiang, Tianzi / Amunts, Katrin / Eickhoff, Simon | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Gehirn & Verhalten; INM-7 Kognitive Neurowissenschaften; INM-3 |
Published in: | NeuroImage, 170 (2018) S. 400-411 |
Imprint: |
Orlando, Fla.
Academic Press
2018
|
PubMed ID: |
28213119 |
DOI: |
10.1016/j.neuroimage.2017.02.034 |
Document Type: |
Journal Article |
Research Program: |
Supercomputing and Modelling for the Human Brain Human Brain Project Specific Grant Agreement 1 Connectivity and Activity |
Link: |
Restricted OpenAccess Restricted |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1016/j.neuroimage.2017.02.034 in citations.
Despite the common conception of the dorsal premotor cortex (PMd) as a single brain region, its diverse connectivity profiles and behavioral heterogeneity argue for a differentiated organization of the PMd. A previous study revealed that the right PMd is characterized by a rostro-caudal and a ventro-dorsal distinction dividing it into five subregions: rostral, central, caudal, ventral and dorsal. The present study assessed whether a similar organization is present in the left hemisphere, by capitalizing on a multimodal data-driven approach combining connectivity-based parcellation (CBP) based on meta-analytic modeling, resting-state functional connectivity, and probabilistic diffusion tractography. The resulting PMd modules were then characterized based on multimodal functional connectivity and a quantitative analysis of associated behavioral functions. Analyzing the clusters consistent across all modalities revealed an organization of the left PMd that mirrored its right counterpart to a large degree. Again, caudal, central and rostral modules reflected a cognitive-motor gradient and a premotor eye-field was found in the ventral part of the left PMd. In addition, a distinct module linked to abstract cognitive functions was observed in the rostro-ventral left PMd across all CBP modalities, implying greater differentiation of higher cognitive functions for the left than the right PMd. |