This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1093/cercor/bhw010 in citations.
Direct Visualization and Mapping of the Spatial Course of Fiber Tracts at Microscopic Resolution in the Human Hippocampus
Direct Visualization and Mapping of the Spatial Course of Fiber Tracts at Microscopic Resolution in the Human Hippocampus
While hippocampal connectivity is essential to normal memory function, our knowledge of human hippocampal circuitry is largely inferred from animal studies. Using polarized light microscopy at 1.3 µm resolution, we have directly visualized the 3D course of key medial temporal pathways in 3 ex vivo h...
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Personal Name(s): | Zeineh, Michael (Corresponding author) |
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Palomero-Gallagher, Nicola / Axer, Markus / Gräβel, David / Goubran, Maged / Wree, Andreas / Woods, Roger / Amunts, Katrin / Zilles, Karl | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 JARA-BRAIN; JARA-BRAIN |
Published in: | Cerebral cortex, 27 (2017) 3, S. 1779-1794 |
Imprint: |
Oxford
Oxford Univ. Press
2017
|
PubMed ID: |
26874183 |
DOI: |
10.1093/cercor/bhw010 |
Document Type: |
Journal Article |
Research Program: |
Postnatal Development of Cortical Receptors and White Matter Tracts in the Vervet Supercomputing and Modelling for the Human Brain Human Brain Project Specific Grant Agreement 1 Connectivity and Activity |
Publikationsportal JuSER |
While hippocampal connectivity is essential to normal memory function, our knowledge of human hippocampal circuitry is largely inferred from animal studies. Using polarized light microscopy at 1.3 µm resolution, we have directly visualized the 3D course of key medial temporal pathways in 3 ex vivo human hemispheres and 2 ex vivo vervet monkey hemispheres. The multiple components of the perforant path system were clearly identified: Superficial sheets of fibers emanating from the entorhinal cortex project to the presubiculum and parasubiculum, intermixed transverse and longitudinal angular bundle fibers perforate the subiculum and then project to the cornu ammonis (CA) fields and dentate molecular layer, and a significant alvear component runs from the angular bundle to the CA fields. From the hilus, mossy fibers localize to regions of high kainate receptor density, and the endfolial pathway, mostly investigated in humans, merges with the Schaffer collaterals. This work defines human hippocampal pathways underlying mnemonic function at an unprecedented resolution. |