Description: Static and dynamic light scattering by red blood cells: A numerical study

This title appears in the Scientific Report : 2017

Static and dynamic light scattering by red blood cells: A numerical study

Light scattering is a well-established experimental technique, which gains more and more popularity in the biological field because it offers the means for non-invasive imaging and detection. However, the interpretation of light-scattering signals remains challenging due to the complexity of most bi...

Personal Name(s):	Mauer, Johannes
	Peltomäki, Matti / Poblete, Simón / Gompper, Gerhard / Fedosov, Dmitry A. (Corresponding author)
Contributing Institute:	Theorie der Weichen Materie und Biophysik; IAS-2 JARA - HPC; JARA-HPC
Published in:	PLoS one, 12 (2017) 5, S. e0176799
Imprint:	Lawrence, Kan. PLoS 2017
DOI:	10.1371/journal.pone.0176799
Document Type:	Journal Article
Research Program:	Blood Flow Resistance in Microvascular Networks Physical Basis of Diseases
Link:	OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/14350 in citations.
Please use the identifier: http://dx.doi.org/10.1371/journal.pone.0176799 in citations.

Light scattering is a well-established experimental technique, which gains more and more popularity in the biological field because it offers the means for non-invasive imaging and detection. However, the interpretation of light-scattering signals remains challenging due to the complexity of most biological systems. Here, we investigate static and dynamic scattering properties of red blood cells (RBCs) using two mesoscopic hydrodynamics simulation methods—multi-particle collision dynamics and dissipative particle dynamics. Light scattering is studied for various membrane shear elasticities, bending rigidities, and RBC shapes (e.g., biconcave and stomatocyte). Simulation results from the two simulation methods show good agreement, and demonstrate that the static light scattering of a diffusing RBC is not very sensitive to the changes in membrane properties and moderate alterations in cell shapes. We also compute dynamic light scattering of a diffusing RBC, from which dynamic properties of RBCs such as diffusion coefficients can be accessed. In contrast to static light scattering, the dynamic measurements can be employed to differentiate between the biconcave and stomatocytic RBC shapes and generally allow the differentiation based on the membrane properties. Our simulation results can be used for better understanding of light scattering by RBCs and the development of new non-invasive methods for blood-flow monitoring.