This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1364/BOE.8.003163 in citations.
Please use the identifier: http://hdl.handle.net/2128/14808 in citations.
Diattenuation of Brain Tissue and its Impact on 3D Polarized Light Imaging
Diattenuation of Brain Tissue and its Impact on 3D Polarized Light Imaging
3D-polarized light imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue – diattenuation. Based on numerical and experimental studies and a complete analytica...
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Personal Name(s): | Menzel, Miriam (Corresponding author) |
---|---|
Reckfort, Julia / Weigand, Daniel / Köse, Hasan / Amunts, Katrin / Axer, Markus | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Biomedical optics express, 8 (2017) 7, S. 3163-3197 |
Imprint: |
Washington, DC
OSA
2017
|
DOI: |
10.1364/BOE.8.003163 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 1 Supercomputing and Modelling for the Human Brain Connectivity and Activity |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/14808 in citations.
3D-polarized light imaging (3D-PLI) reconstructs nerve fibers in histological brain sections by measuring their birefringence. This study investigates another effect caused by the optical anisotropy of brain tissue – diattenuation. Based on numerical and experimental studies and a complete analytical description of the optical system, the diattenuation was determined to be below 4 % in rat brain tissue. It was demonstrated that the diattenuation effect has negligible impact on the fiber orientations derived by 3D-PLI. The diattenuation signal, however, was found to highlight different anatomical structures that cannot be distinguished with current imaging techniques, which makes Diattenuation Imaging a promising extension to 3D-PLI. |