This title appears in the Scientific Report :
2017
Please use the identifier:
http://dx.doi.org/10.1109/ISBI.2017.7950666 in citations.
Please use the identifier: http://hdl.handle.net/2128/15198 in citations.
Parcellation of visual cortex on high-resolution histological brain sections using convolutional neural networks
Parcellation of visual cortex on high-resolution histological brain sections using convolutional neural networks
Microscopic analysis of histological sections is considered the “gold standard” to verify structural parcellations in the human brain. Its high resolution allows the study of laminar and columnar patterns of cell distributions, which build an important basis for the simulation of cortical areas and...
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Personal Name(s): | Spitzer, Hannah (Corresponding author) |
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Amunts, Katrin / Harmeling, Stefan / Dickscheid, Timo | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Imprint: |
IEEE
2017
|
Physical Description: |
920-923 |
DOI: |
10.1109/ISBI.2017.7950666 |
Conference: | 2017 IEEE 14th International Symposium on Biomedical Imaging (ISBI 2017), Melbourne (Australia), 2017-04-18 - 2017-04-21 |
Document Type: |
Contribution to a conference proceedings |
Research Program: |
Supercomputing and Modelling for the Human Brain Human Brain Project Specific Grant Agreement 1 Theory, modelling and simulation |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/15198 in citations.
Microscopic analysis of histological sections is considered the “gold standard” to verify structural parcellations in the human brain. Its high resolution allows the study of laminar and columnar patterns of cell distributions, which build an important basis for the simulation of cortical areas and networks. However, such cytoarchitectonic mapping is a semiautomatic, time consuming process that does not scale with high throughput imaging. We present an automatic approach for parcellating histological sections at 2µm resolution. It is based on a convolutional neural network that combines topological information from probabilistic atlases with the texture features learned from high-resolution cell-body stained images. The model is applied to visual areas and trained on a sparse set of partial annotations. We show how predictions are transferable to new brains and spatially consistent across sections. |