This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.2967/jnumed.117.196709 in citations.
Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study
Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study
PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomi...
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Personal Name(s): | Mauler, Jörg (Corresponding author) |
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Maudsley, Andrew A. / Langen, Karl-Josef / Nikoubashman, Omid / Stoffels, Gabriele / Sheriff, Sulaiman / Lohmann, Philipp / Filss, Christian / Galldiks, Norbert / Rota Kops, Elena / Shah, N. J. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 Physik der Medizinischen Bildgebung; INM-4 |
Published in: | Journal of nuclear medicine, 59 (2018) 4, S. 603-609 |
Imprint: |
New York, NY
Soc.
2018
|
DOI: |
10.2967/jnumed.117.196709 |
PubMed ID: |
28848036 |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
PET imaging of amino acid transport using O-(2-18F-fluoroethyl)-l-tyrosine (18F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to N-acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. Methods: In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in 18F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Results: The average tumor volumes for 18F-FET uptake and increased Cho/NAA were 19 ± 20 cm3 (mean ± SD) and 22 ± 24 cm3, respectively, with an overlap of 40% ± 25% and separation of the centers of mass by 9 ± 8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion: 18F-FET uptake and increased Cho/NAA ratio are not always congruent and may represent different properties of glioma metabolism. The relationship to histologic tumor extent needs to be further analyzed. |