This title appears in the Scientific Report :
2018
Please use the identifier:
http://hdl.handle.net/2128/17604 in citations.
Please use the identifier: http://dx.doi.org/10.1021/acs.jmedchem.7b01388 in citations.
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on human cancer cells, endorsing their further exp...
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Personal Name(s): | Ortega, Jose Antonio |
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Riccardi, Laura / Minniti, Elirosa / Borgogno, Marco / Arencibia, Jose M. / Greco, Maria L. / Minarini, Anna / Sissi, Claudia (Corresponding author) / De Vivo, Marco (Corresponding author) | |
Contributing Institute: |
Computational Biomedicine; INM-9 Computational Biomedicine; IAS-5 |
Published in: | Journal of medicinal chemistry, 61 (2018) 3, S. 1375-1379 |
Imprint: |
Washington, DC
ACS
2018
|
DOI: |
10.1021/acs.jmedchem.7b01388 |
PubMed ID: |
29077404 |
Document Type: |
Journal Article |
Research Program: |
Theory, modelling and simulation |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1021/acs.jmedchem.7b01388 in citations.
We used a pharmacophore hybridization strategy to combine key structural elements of merbarone and etoposide and generated new type II topoisomerase (topoII) poisons. This first set of hybrid topoII poisons shows promising antiproliferative activity on human cancer cells, endorsing their further exploration for anticancer drug discovery. |