This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.1038/s41598-018-21952-3 in citations.
Please use the identifier: http://hdl.handle.net/2128/17555 in citations.
Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1
Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1
Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the...
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Personal Name(s): | Milić, Dalibor |
---|---|
Dick, Markus / Mulnaes, Daniel / Pfleger, Christopher / Kinnen, Anna / Gohlke, Holger (Corresponding author) / Groth, Georg (Corresponding author) | |
Contributing Institute: |
Strukturbiochemie; ICS-6 John von Neumann - Institut für Computing; NIC Jülich Supercomputing Center; JSC |
Published in: | Scientific reports, 8 (2018) 1, S. 3890 |
Imprint: |
London
Nature Publishing Group
2018
|
DOI: |
10.1038/s41598-018-21952-3 |
PubMed ID: |
29497085 |
Document Type: |
Journal Article |
Research Program: |
Forschergruppe Gohlke Bioeconomy Science Center Plant Science Theory, modelling and simulation Computational Science and Mathematical Methods |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/17555 in citations.
Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 – the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism for the ripening inhibition. |