This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.1038/s41598-018-23100-3 in citations.
Please use the identifier: http://hdl.handle.net/2128/18496 in citations.
Tunable Ampere phase plate for low dose imaging of biomolecular complexes
Tunable Ampere phase plate for low dose imaging of biomolecular complexes
A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of a segment of current-carrying wire that is oriented paralle...
Saved in:
Personal Name(s): | Tavabi, Amir Hossein (Corresponding author) |
---|---|
Beleggia, Marco / Migunov, Vadim / Savenko, Alexey / Öktem, Ozan / Dunin-Borkowski, Rafal / Pozzi, Giulio | |
Contributing Institute: |
Physik Nanoskaliger Systeme; ER-C-1 Materialwissenschaft u. Werkstofftechnik; ER-C-2 |
Published in: | Scientific reports, 8 (2018) 1, S. 5592 |
Imprint: |
London
Nature Publishing Group
2018
|
PubMed ID: |
29618785 |
DOI: |
10.1038/s41598-018-23100-3 |
Document Type: |
Journal Article |
Research Program: |
Controlling Configuration-Based Phenomena |
Link: |
Get full text Get full text OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/18496 in citations.
A novel device that can be used as a tunable support-free phase plate for transmission electron microscopy of weakly scattering specimens is described. The device relies on the generation of a controlled phase shift by the magnetic field of a segment of current-carrying wire that is oriented parallel or antiparallel to the electron beam. The validity of the concept is established using both experimental electron holographic measurements and a theoretical model based on Ampere’s law. Computer simulations are used to illustrate the resulting contrast enhancement for studies of biological cells and macromolecules. |