This title appears in the Scientific Report :
2019
Please use the identifier:
http://hdl.handle.net/2128/21727 in citations.
Please use the identifier: http://dx.doi.org/10.1093/cercor/bhy245 in citations.
Cytoarchitectonic segregation of human posterior intraparietal and adjacent parieto-occipital sulcus and its relation to visuomotor and cognitive functions
Cytoarchitectonic segregation of human posterior intraparietal and adjacent parieto-occipital sulcus and its relation to visuomotor and cognitive functions
Human posterior intraparietal sulcus (pIPS) and adjacent posterior wall of parieto-occipital sulcus (POS) are functionally diverse, serving higher motor, visual and cognitive functions. Its microstructural basis, though, is still largely unknown. A similar or even more pronounced architectonical com...
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Personal Name(s): | Richter, Monika |
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Amunts, Katrin / Mohlberg, Hartmut / Bludau, Sebastian / Eickhoff, Simon / Zilles, Karl / Caspers, Svenja (Corresponding author) | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 Gehirn & Verhalten; INM-7 |
Published in: | Cerebral cortex, 29 (2019) 3, S. 1305–1327 |
Imprint: |
Oxford
Oxford Univ. Press
2019
|
PubMed ID: |
30561508 |
DOI: |
10.1093/cercor/bhy245 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 1 Supercomputing and Modelling for the Human Brain Connectivity and Activity |
Link: |
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Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1093/cercor/bhy245 in citations.
Human posterior intraparietal sulcus (pIPS) and adjacent posterior wall of parieto-occipital sulcus (POS) are functionally diverse, serving higher motor, visual and cognitive functions. Its microstructural basis, though, is still largely unknown. A similar or even more pronounced architectonical complexity, as described in monkeys, could be assumed. We cytoarchitectonically mapped the pIPS/POS in 10 human postmortem brains using an observer-independent, quantitative parcellation. 3D-probability maps were generated within MNI reference space and used for functional decoding and meta-analytic coactivation modeling based on the BrainMap database to decode the general structural–functional organization of the areas. Seven cytoarchitectonically distinct areas were identified: five within human pIPS, three on its lateral (hIP4-6) and two on its medial wall (hIP7-8); and two (hPO1, hOc6) in POS. Mediocaudal areas (hIP7, hPO1) were predominantly involved in visual processing, whereas laterorostral areas (hIP4-6, 8) were associated with higher cognitive functions, e.g. counting. This shift was mirrored by systematic changes in connectivity, from temporo-occipital to premotor and prefrontal cortex, and in cytoarchitecture, from prominent Layer IIIc pyramidal cells to homogeneous neuronal distribution. This architectonical mosaic within human pIPS/POS represents a structural basis of its functional and connectional heterogeneity. The new 3D-maps of the areas enable dedicated assessments of structure–function relationships. |