This title appears in the Scientific Report :
2018
Real-Time Microwave Characterization of Low-Molecular-Weight Antioxidant Biomarkers.
Real-Time Microwave Characterization of Low-Molecular-Weight Antioxidant Biomarkers.
This work presents the results of an accurate real-time microwave characterization of low-molecular-weight antioxidant biomarkers in low-volume solutions using a high-Q whispering gallery-mode dielectric resonator with a microfluidic channel. Sodium ascorbate and glutathione were characterized as th...
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Personal Name(s): | Naumova, Natallia |
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Hlukhova, Hanna / Barannik / Gubin / Protsenko / Cherpak / Vitusevich, Svetlana (Corresponding author) | |
Contributing Institute: |
Bioelektronik; ICS-8 |
Imprint: |
Warsaw University of Technology
978-83-949421-0-6
2018
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Conference: | 22nd International Microwave and Radar Conference MIKON, Poznan (Poland), 2018-05-14 - 2018-05-18 |
Document Type: |
Proceedings |
Research Program: |
Controlling Configuration-Based Phenomena |
Publikationsportal JuSER |
This work presents the results of an accurate real-time microwave characterization of low-molecular-weight antioxidant biomarkers in low-volume solutions using a high-Q whispering gallery-mode dielectric resonator with a microfluidic channel. Sodium ascorbate and glutathione were characterized as the most significant non-enzymatic biomarkers of oxidative stress with respect to the reactive oxygen species scavenging system of cells. Microwave characterization was performed using a high-Q whispering-gallery-mode dielectric resonator with a microfluidic channel. The experiments demonstrated a fast response with high sensitivity in detecting sodium ascorbate and glutathione of different concentrations in biological solutions of small nanoliter volumes at a resonance frequency of about 35.5 GHz. These results indicate great potential for applying real-time microwave whispering-gallery-mode biosensing techniques in the characterization of low-molecular-weight antioxidant-specific biomarkers, which could be used in the laboratory and clinical biomedical research. |