This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.1088/1361-6528/aaaf9e in citations.
Origin of noise in liquid-gated Si nanowire troponin biosensors
Origin of noise in liquid-gated Si nanowire troponin biosensors
Liquid-gated Si nanowire field-effect transistor (FET) biosensors are fabricated using a complementary metal-oxide-semiconductor-compatible top-down approach. The transport and noise properties of the devices reflect the high performance of the FET structures, which allows label-free detection of ca...
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Personal Name(s): | Kutovyi, Y. |
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Zadorozhnyi, I. / Hlukhova, H. / Handziuk, V. / Petrychuk, M. / Ivanchuk, Andriy / Vitusevich, S. (Corresponding author) | |
Contributing Institute: |
Bioelektronik; ICS-8 |
Published in: | Nanotechnology, 29 (2018) 17, S. 175202 -1-11 |
Imprint: |
Bristol
IOP Publ.
2018
|
DOI: |
10.1088/1361-6528/aaaf9e |
PubMed ID: |
29446349 |
Document Type: |
Journal Article |
Research Program: |
Controlling Configuration-Based Phenomena |
Publikationsportal JuSER |
Liquid-gated Si nanowire field-effect transistor (FET) biosensors are fabricated using a complementary metal-oxide-semiconductor-compatible top-down approach. The transport and noise properties of the devices reflect the high performance of the FET structures, which allows label-free detection of cardiac troponin I (cTnI) molecules. Moreover, after removing the troponin antigens the structures demonstrate the same characteristics as before cTnI detection, indicating the reusable operation of biosensors. Our results show that the additional noise is related to the troponin molecules and has characteristics which considerably differ from those usually recorded for conventional FETs without target molecules. We describe the origin of the noise and suggest that noise spectroscopy represents a powerful tool for understanding molecular dynamic processes in nanoscale FET-based biosensors. |