This title appears in the Scientific Report : 2018 

Analysis of shared heritability in common disorders of the brain
Anttila, Verneri (Corresponding author)
Bulik-Sullivan, Brendan / Finucane, Hilary K. / Walters, Raymond K. / Bras, Jose / Duncan, Laramie / Escott-Price, Valentina / Falcone, Guido J. / Gormley, Padhraig / Malik, Rainer / Patsopoulos, Nikolaos A. / Ripke, Stephan / Wei, Zhi / Yu, Dongmei / Lee, Phil H. / Turley, Patrick / Grenier-Boley, Benjamin / Chouraki, Vincent / Kamatani, Yoichiro / Berr, Claudine / Letenneur, Luc / Hannequin, Didier / Amouyel, Philippe / Boland, Anne / Deleuze, Jean-François / Duron, Emmanuelle / Vardarajan, Badri N. / Reitz, Christiane / Goate, Alison M. / Huentelman, Matthew J. / Kamboh, M. Ilyas / Larson, Eric B. / Rogaeva, Ekaterina / St George-Hyslop, Peter / Hakonarson, Hakon / Kukull, Walter A. / Farrer, Lindsay A. / Barnes, Lisa L. / Beach, Thomas G. / Demirci, F. Yesim / Head, Elizabeth / Hulette, Christine M. / Jicha, Gregory A. / Kauwe, John S. K. / Kaye, Jeffrey A. / Leverenz, James B. / Levey, Allan I. / Lieberman, Andrew P. / Pankratz, Vernon S. / Poon, Wayne W. / Quinn, Joseph F. / Saykin, Andrew J. / Schneider, Lon S. / Smith, Amanda G. / Sonnen, Joshua A. / Stern, Robert A. / Van Deerlin, Vivianna M. / Van Eldik, Linda J. / Harold, Denise / Russo, Giancarlo / Rubinsztein, David C. / Bayer, Anthony / Tsolaki, Magda / Proitsi, Petra / Fox, Nick C. / Hampel, Harald / Owen, Michael J. / Mead, Simon / Passmore, Peter / Morgan, Kevin / Nöthen, Markus M. / Schott, Jonathan M. / Rossor, Martin / Lupton, Michelle K. / Hoffmann, Per / Kornhuber, Johannes / Lawlor, Brian / McQuillin, Andrew / Al-Chalabi, Ammar / Bis, Joshua C / Ruiz, Agustin / Boada, Mercè / Seshadri, Sudha / Beiser, Alexa / Rice, Kenneth / van der Lee, Sven J. / De Jager, Philip L. / Geschwind, Daniel H. / Riemenschneider, Matthias / Riedel-Heller, Steffi / Rotter, Jerome I / Ransmayr, Gerhard / Hyman, Bradley T. / Cruchaga, Carlos / Alegret, Montserrat / Winsvold, Bendik / Palta, Priit / Farh, Kai-How / Cuenca-Leon, Ester / Furlotte, Nicholas / Kurth, Tobias / Ligthart, Lannie / Terwindt, Gisela M. / Freilinger, Tobias / Ran, Caroline / Gordon, Scott D. / Borck, Guntram / Adams, Hieab H. H. / Lehtimäki, Terho / Wedenoja, Juho / Buring, Julie E. / Schürks, Markus / Hrafnsdottir, Maria / Hottenga, Jouke-Jan / Penninx, Brenda / Artto, Ville / Kaunisto, Mari / Vepsäläinen, Salli / Martin, Nicholas G. / Montgomery, Grant W. / Kurki, Mitja I. / Hämäläinen, Eija / Huang, Hailiang / Huang, Jie / Sandor, Cynthia / Webber, Caleb / Muller-Myhsok, Bertram / Schreiber, Stefan / Salomaa, Veikko / Loehrer, Elizabeth / Göbel, Hartmut / Macaya, Alfons / Pozo-Rosich, Patricia / Hansen, Thomas / Werge, Thomas / Kaprio, Jaakko / Metspalu, Andres / Kubisch, Christian / Ferrari, Michel D. / Belin, Andrea C. / van den Maagdenberg, Arn M. J. M. / Zwart, John-Anker / Boomsma, Dorret / Eriksson, Nicholas / Olesen, Jes / Chasman, Daniel I. / Nyholt, Dale R. / Anney, Richard / Avbersek, Andreja / Baum, Larry / Berkovic, Samuel / Bradfield, Jonathan / Buono, Russell / Catarino, Claudia B. / Cossette, Patrick / De Jonghe, Peter / Depondt, Chantal / Dlugos, Dennis / Ferraro, Thomas N. / French, Jacqueline / Hjalgrim, Helle / Jamnadas-Khoda, Jennifer / Kälviäinen, Reetta / Kunz, Wolfram S. / Lerche, Holger / Leu, Costin / Lindhout, Dick / Lo, Warren / Lowenstein, Daniel / McCormack, Mark / Møller, Rikke S. / Molloy, Anne / Ng, Ping-Wing / Oliver, Karen / Privitera, Michael / Radtke, Rodney / Ruppert, Ann-Kathrin / Sander, Thomas / Schachter, Steven / Schankin, Christoph / Scheffer, Ingrid / Schoch, Susanne / Sisodiya, Sanjay M. / Smith, Philip / Sperling, Michael / Striano, Pasquale / Surges, Rainer / Thomas, G. Neil / Visscher, Frank / Whelan, Christopher D. / Zara, Federico / Heinzen, Erin L. / Marson, Anthony / Becker, Felicitas / Stroink, Hans / Zimprich, Fritz / Gasser, Thomas / Gibbs, Raphael / Heutink, Peter / Martinez, Maria / Morris, Huw R. / Sharma, Manu / Ryten, Mina / Mok, Kin Y. / Pulit, Sara / Bevan, Steve / Holliday, Elizabeth / Attia, John / Battey, Thomas / Boncoraglio, Giorgio / Thijs, Vincent / Chen, Wei-Min / Mitchell, Braxton / Rothwell, Peter / Sharma, Pankaj / Sudlow, Cathie / Vicente, Astrid / Markus, Hugh / Kourkoulis, Christina / Pera, Joana / Raffeld, Miriam / Silliman, Scott / Boraska Perica, Vesna / Thornton, Laura M. / Huckins, Laura M. / William Rayner, N. / Lewis, Cathryn M. / Gratacos, Monica / Rybakowski, Filip / Keski-Rahkonen, Anna / Raevuori, Anu / Hudson, James I. / Reichborn-Kjennerud, Ted / Monteleone, Palmiero / Karwautz, Andreas / Mannik, Katrin / Baker, Jessica H. / O’Toole, Julie K. / Trace, Sara E. / Davis, Oliver S. P. / Helder, Sietske G. / Ehrlich, Stefan / Herpertz-Dahlmann, Beate / Danner, Unna N. / van Elburg, Annemarie A. / Clementi, Maurizio / Forzan, Monica / Docampo, Elisa / Lissowska, Jolanta / Hauser, Joanna / Tortorella, Alfonso / Maj, Mario / Gonidakis, Fragiskos / Tziouvas, Konstantinos / Papezova, Hana / Yilmaz, Zeynep / Wagner, Gudrun / Cohen-Woods, Sarah / Herms, Stefan / Julià, Antonio / Rabionet, Raquel / Dick, Danielle M. / Ripatti, Samuli / Andreassen, Ole A. / Espeseth, Thomas / Lundervold, Astri J. / Steen, Vidar M. / Pinto, Dalila / Scherer, Stephen W. / Aschauer, Harald / Schosser, Alexandra / Alfredsson, Lars / Padyukov, Leonid / Halmi, Katherine A. / Mitchell, James / Strober, Michael / Bergen, Andrew W. / Kaye, Walter / Szatkiewicz, Jin Peng / Cormand, Bru / Ramos-Quiroga, Josep Antoni / Sánchez-Mora, Cristina / Ribasés, Marta / Casas, Miguel / Hervas, Amaia / Arranz, Maria Jesús / Haavik, Jan / Zayats, Tetyana / Johansson, Stefan / Williams, Nigel / Elia, Josephine / Dempfle, Astrid / Rothenberger, Aribert / Kuntsi, Jonna / Oades, Robert D. / Banaschewski, Tobias / Franke, Barbara / Buitelaar, Jan K. / Arias Vasquez, Alejandro / Doyle, Alysa E. / Reif, Andreas / Lesch, Klaus-Peter / Freitag, Christine / Rivero, Olga / Palmason, Haukur / Romanos, Marcel / Langley, Kate / Rietschel, Marcella / Witt, Stephanie H. / Dalsgaard, Soeren / Børglum, Anders D. / Waldman, Irwin / Wilmot, Beth / Molly, Nikolas / Bau, Claiton H. D. / Crosbie, Jennifer / Schachar, Russell / Loo, Sandra K. / McGough, James J. / Grevet, Eugenio H. / Medland, Sarah E. / Robinson, Elise / Weiss, Lauren A. / Bacchelli, Elena / Bailey, Anthony / Bal, Vanessa / Battaglia, Agatino / Betancur, Catalina / Bolton, Patrick / Cantor, Rita / Celestino-Soper, Patrícia / Dawson, Geraldine / De Rubeis, Silvia / Duque, Frederico / Green, Andrew / Klauck, Sabine M. / Leboyer, Marion / Levitt, Pat / Maestrini, Elena / Mane, Shrikant / De-Luca, Daniel Moreno- / Parr, Jeremy / Regan, Regina / Reichenberg, Abraham / Sandin, Sven / Vorstman, Jacob / Wassink, Thomas / Wijsman, Ellen / Cook, Edwin / Santangelo, Susan / Delorme, Richard / Rogé, Bernadette / Magalhaes, Tiago / Arking, Dan / Schulze, Thomas G. / Thompson, Robert C. / Strohmaier, Jana / Matthews, Keith / Melle, Ingrid / Morris, Derek / Blackwood, Douglas / McIntosh, Andrew / Bergen, Sarah E / Schalling, Martin / Jamain, Stéphane / Maaser, Anna / Fischer, Sascha B. / Reinbold, Céline S. / Fullerton, Janice M. / Grigoroiu-Serbanescu, Maria / Guzman-Parra, José / Mayoral, Fermin / Schofield, Peter R. / Cichon, Sven / Mühleisen, Thomas / Degenhardt, Franziska / Schumacher, Johannes / Bauer, Michael / Mitchell, Philip B. / Gershon, Elliot S. / Rice, John / Potash, James B. / Zandi, Peter P. / Craddock, Nick / Ferrier, I. Nicol / Alda, Martin / Rouleau, Guy A. / Turecki, Gustavo / Ophoff, Roel / Pato, Carlos / Anjorin, Adebayo / Stahl, Eli / Leber, Markus / Czerski, Piotr M. / Edenberg, Howard J. / Cruceanu, Cristiana / Jones, Ian R. / Posthuma, Danielle / Andlauer, Till F. M. / Forstner, Andreas J. / Streit, Fabian / Baune, Bernhard T. / Air, Tracy / Sinnamon, Grant / Wray, Naomi R. / MacIntyre, Donald J. / Porteous, David / Homuth, Georg / Rivera, Margarita / Grove, Jakob / Middeldorp, Christel M. / Hickie, Ian / Pergadia, Michele / Mehta, Divya / Smit, Johannes H. / Jansen, Rick / de Geus, Eco / Dunn, Erin / Li, Qingqin S. / Nauck, Matthias / Schoevers, Robert A. / Beekman, Aartjan TF / Knowles, James A. / Viktorin, Alexander / Arnold, Paul / Barr, Cathy L. / Bedoya-Berrio, Gabriel / Bienvenu, O. Joseph / Brentani, Helena / Burton, Christie / Camarena, Beatriz / Cappi, Carolina / Cath, Danielle / Cavallini, Maria / Cusi, Daniele / Darrow, Sabrina / Denys, Damiaan / Derks, Eske M. / Dietrich, Andrea / Fernandez, Thomas / Figee, Martijn / Freimer, Nelson / Gerber, Gloria / Grados, Marco / Greenberg, Erica / Hanna, Gregory L. / Hartmann, Andreas / Hirschtritt, Matthew E. / Hoekstra, Pieter J. / Huang, Alden / Huyser, Chaim / Illmann, Cornelia / Jenike, Michael / Kuperman, Samuel / Leventhal, Bennett / Lochner, Christine / Lyon, Gholson J. / Macciardi, Fabio / Madruga-Garrido, Marcos / Malaty, Irene A. / Maras, Athanasios / McGrath, Lauren / Miguel, Eurípedes C. / Mir, Pablo / Nestadt, Gerald / Nicolini, Humberto / Okun, Michael S. / Pakstis, Andrew / Paschou, Peristera / Piacentini, John / Pittenger, Christopher / Plessen, Kerstin / Ramensky, Vasily / Ramos, Eliana M. / Reus, Victor / Richter, Margaret A. / Riddle, Mark A. / Robertson, Mary M. / Roessner, Veit / Rosário, Maria / Samuels, Jack F. / Sandor, Paul / Stein, Dan J. / Tsetsos, Fotis / Van Nieuwerburgh, Filip / Weatherall, Sarah / Wendland, Jens R. / Wolanczyk, Tomasz / Worbe, Yulia / Zai, Gwyneth / Goes, Fernando S. / McLaughlin, Nicole / Nestadt, Paul S. / Grabe, Hans-Jorgen / Depienne, Christel / Konkashbaev, Anuar / Lanzagorta, Nuria / Valencia-Duarte, Ana / Bramon, Elvira / Buccola, Nancy / Cahn, Wiepke / Cairns, Murray / Chong, Siow A. / Cohen, David / Crespo-Facorro, Benedicto / Crowley, James / Davidson, Michael / DeLisi, Lynn / Dinan, Timothy / Donohoe, Gary / Drapeau, Elodie / Duan, Jubao / Haan, Lieuwe / Hougaard, David / Karachanak-Yankova, Sena / Khrunin, Andrey / Klovins, Janis / Kučinskas, Vaidutis / Lee Chee Keong, Jimmy / Limborska, Svetlana / Loughland, Carmel / Lönnqvist, Jouko / Maher, Brion / Mattheisen, Manuel / McDonald, Colm / Murphy, Kieran C. / Murray, Robin / Nenadic, Igor / van Os, Jim / Pantelis, Christos / Pato, Michele / Petryshen, Tracey / Quested, Digby / Roussos, Panos / Sanders, Alan R. / Schall, Ulrich / Schwab, Sibylle G. / Sim, Kang / So, Hon-Cheong / Stögmann, Elisabeth / Subramaniam, Mythily / Toncheva, Draga / Waddington, John / Walters, James / Weiser, Mark / Cheng, Wei / Cloninger, Robert / Curtis, David / Gejman, Pablo V. / Henskens, Frans / Mattingsdal, Morten / Oh, Sang-Yun / Scott, Rodney / Webb, Bradley / Breen, Gerome / Churchhouse, Claire / Bulik, Cynthia M. / Daly, Mark / Dichgans, Martin / Faraone, Stephen V. / Guerreiro, Rita / Holmans, Peter / Kendler, Kenneth S. / Koeleman, Bobby / Mathews, Carol A. / Price, Alkes / Scharf, Jeremiah / Sklar, Pamela / Williams, Julie / Wood, Nicholas W. / Cotsapas, Chris / Palotie, Aarno / Smoller, Jordan W. / Sullivan, Patrick / Rosand, Jonathan / Corvin, Aiden (Corresponding author) / Neale, Benjamin M. (Corresponding author)
Strukturelle und funktionelle Organisation des Gehirns; INM-1
Science, 360 (2018) 6395, S. eaap8757 -
Washington, DC [u.a.] American Association for the Advancement of Science64196 2018
10.1126/science.aap8757
29930110
Journal Article
Connectivity and Activity
Please use the identifier: http://dx.doi.org/10.1126/science.aap8757 in citations.
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.