This title appears in the Scientific Report :
2018
Please use the identifier:
http://dx.doi.org/10.1038/s42003-018-0155-y in citations.
Please use the identifier: http://hdl.handle.net/2128/19841 in citations.
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic...
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Personal Name(s): | de Jong, Simone |
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Diniz, Mateus Jose Abdalla / Saloma, Andiara / Gadelha, Ary / Santoro, Marcos L. / Ota, Vanessa K. / Noto, Cristiano / Consortium, Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics (Collaboration author) / Cichon, Sven / Curtis, Charles / Newhouse, Stephen J. / Patel, Hamel / Hall, Lynsey S. / O`Reilly, Paul F. / Belangero, Sintia I. / Bressan, Rodrigo A. / Breen, Gerome (Corresponding author) | |
Contributing Institute: |
Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Communications biology, 1 (2018) 1, S. 163 |
Imprint: |
London
Springer Nature
2018
|
PubMed ID: |
30320231 |
DOI: |
10.1038/s42003-018-0155-y |
Document Type: |
Journal Article |
Research Program: |
Connectivity and Activity |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/19841 in citations.
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generations. This may explain the observation of anticipation in mood disorders, whereby onset is earlier and the severity increases over the generations of a family. Joint analyses of rare and common variation may be a powerful way to understand the familial genetics of psychiatric disorders |