This title appears in the Scientific Report :
2019
Please use the identifier:
http://hdl.handle.net/2128/23683 in citations.
Please use the identifier: http://dx.doi.org/10.1093/cercor/bhy336 in citations.
Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient
Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient
The hippocampus displays a complex organization and function that is perturbed in many neuropathologies. Histological work revealed a complex arrangement of subfields along the medial–lateral and the ventral–dorsal dimension, which contrasts with the anterior–posterior functional differentiation. Th...
Saved in:
Personal Name(s): | Plachti, Anna (Corresponding author) |
---|---|
Eickhoff, Simon / Hoffstaedter, Felix / Patil, Kaustubh / Laird, Angela R / Fox, Peter T / Amunts, Katrin / Genon, Sarah | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Cerebral cortex, 29 (2019) 11, S. 4595-4612 |
Imprint: |
Oxford
Oxford Univ. Press
2019
|
DOI: |
10.1093/cercor/bhy336 |
PubMed ID: |
30721944 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 1 Supercomputing and Modelling for the Human Brain Connectivity and Activity |
Link: |
Get full text Get full text OpenAccess OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.1093/cercor/bhy336 in citations.
The hippocampus displays a complex organization and function that is perturbed in many neuropathologies. Histological work revealed a complex arrangement of subfields along the medial–lateral and the ventral–dorsal dimension, which contrasts with the anterior–posterior functional differentiation. The variety of maps has raised the need for an integrative multimodal view. We applied connectivity-based parcellation to 1) intrinsic connectivity 2) task-based connectivity, and 3) structural covariance, as complementary windows into structural and functional differentiation of the hippocampus. Strikingly, while functional properties (i.e., intrinsic and task-based) revealed similar partitions dominated by an anterior–posterior organization, structural covariance exhibited a hybrid pattern reflecting both functional and cytoarchitectonic subdivision. Capitalizing on the consistency of functional parcellations, we defined robust functional maps at different levels of partitions, which are openly available for the scientific community. Our functional maps demonstrated a head–body and tail partition, subdivided along the anterior–posterior and medial–lateral axis. Behavioral profiling of these fine partitions based on activation data indicated an emotion–cognition gradient along the anterior–posterior axis and additionally suggested a self-world-centric gradient supporting the role of the hippocampus in the construction of abstract representations for spatial navigation and episodic memory. |