This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.1038/s41467-019-08500-x in citations.
Please use the identifier: http://hdl.handle.net/2128/21585 in citations.
Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focusedon the effects of single lifestyle variables. Here, we studied the combined and individualcontributions of four lifestyle variables - alcohol consumption, smoking, physical activity,and social integrati...
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Personal Name(s): | Bittner, Nora |
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Jockwitz, Christiane / Mühleisen, Thomas W. / Hoffstaedter, Felix / Eickhoff, Simon / Moebus, Susanne / Bayen, Ute J. / Cichon, Sven / Zilles, Karl / Amunts, Katrin / Caspers, Svenja (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 Strukturelle und funktionelle Organisation des Gehirns; INM-1 |
Published in: | Nature Communications, 10 (2019) 1, S. 621 |
Imprint: |
[London]
Nature Publishing Group UK
2019
|
DOI: |
10.1038/s41467-019-08500-x |
PubMed ID: |
30728360 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 1 Connectivity and Activity |
Link: |
Get full text OpenAccess OpenAccess Get full text |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/21585 in citations.
Lifestyle contributes to inter-individual variability in brain aging, but previous studies focusedon the effects of single lifestyle variables. Here, we studied the combined and individualcontributions of four lifestyle variables - alcohol consumption, smoking, physical activity,and social integration - to brain structure and functional connectivity in a population-basedcohort of 549 older adults. A combined lifestyle risk score was associated with decreasedgyrification in left premotor and right prefrontal cortex, and higher functional connectivityto sensorimotor and prefrontal cortex. While structural differences were driven by alcoholconsumption, physical activity, and social integration, higher functional connectivity wasdriven by smoking. Results suggest that combining differentially contributing lifestylevariables may be more than the sum of its parts. Associations generally were neither alteredby adjustment for genetic risk, nor by depressive symptomatology or education, underliningthe relevance of daily habits for brain health. |