This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.1039/C8DT04996C in citations.
52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity
Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve...
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Personal Name(s): | Brandt, Marie R. |
---|---|
Vanasschen, Christian / Ermert, Johannes (Corresponding author) / Coenen, Heinz H. / Neumaier, Bernd | |
Contributing Institute: |
Nuklearchemie; INM-5 |
Published in: | Dalton transactions, 48 (2019) 9, S. 3003 - 3008 |
Imprint: |
London
Soc.
2019
|
PubMed ID: |
30747205 |
DOI: |
10.1039/C8DT04996C |
Document Type: |
Journal Article |
Research Program: |
Neuroimaging |
Publikationsportal JuSER |
Trans-1,2-diaminocyclohexane-N,N,N‘,N‘-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography /Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets. |