This title appears in the Scientific Report :
2019
Please use the identifier:
http://hdl.handle.net/2128/22185 in citations.
Please use the identifier: http://dx.doi.org/10.7554/eLife.43464 in citations.
Empirical examination of the replicability of associations between brain structure and psychological variables
Empirical examination of the replicability of associations between brain structure and psychological variables
Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported 'structural brain behavior' (SBB)-associations has been questione...
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Personal Name(s): | Kharabian, Shahrzad (Corresponding author) |
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Eickhoff, Simon / Hoffstaedter, Felix / GENON, Sarah (Corresponding author) | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | eLife, 8 (2019) S. e43464 |
Imprint: |
Cambridge
eLife Sciences Publications
2019
|
PubMed ID: |
30864950 |
DOI: |
10.7554/eLife.43464 |
Document Type: |
Journal Article |
Research Program: |
Human Brain Project Specific Grant Agreement 2 Human Brain Project Specific Grant Agreement 1 Supercomputing and Modelling for the Human Brain Theory, modelling and simulation |
Link: |
OpenAccess OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.7554/eLife.43464 in citations.
Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported 'structural brain behavior' (SBB)-associations has been questioned, recently. Here, we conducted an empirical investigation, assessing replicability of SBB among heathy adults. For a wide range of psychological measures, the replicability of associations with gray matter volume was assessed. Our results revealed that among healthy individuals 1) finding an association between performance at standard psychological tests and brain morphology is relatively unlikely 2) significant associations, found using an exploratory approach, have overestimated effect sizes and 3) can hardly be replicated in an independent sample. After considering factors such as sample size and comparing our findings with more replicable SBB-associations in a clinical cohort and replicable associations between brain structure and non-psychological phenotype, we discuss the potential causes and consequences of these findings. |