Biophysikalische Charakterisierung eines Protonenstrahls im Hinblick auf eine Optimierung der Bestrahlungsplanung von Tumoren
Biophysikalische Charakterisierung eines Protonenstrahls im Hinblick auf eine Optimierung der Bestrahlungsplanung von Tumoren
Radiation therapy is highly depending on precise model predictions of the dose effects on tumour and normal tissues. To investigate and prove such models the biological and the physical impact of radiation have to be characterized. This enables to correlate the physical radiation quality with biolog...
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Personal Name(s): | Becker, R. (Corresponding author) |
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Contributing Institute: |
Publikationen vor 2000; PRE-2000; Retrocat |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
1997
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Physical Description: |
129 p. |
Document Type: |
Report Book |
Research Program: |
ohne Topic |
Series Title: |
Berichte des Forschungszentrums Jülich
3423 |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Radiation therapy is highly depending on precise model predictions of the dose effects on tumour and normal tissues. To investigate and prove such models the biological and the physical impact of radiation have to be characterized. This enables to correlate the physical radiation quality with biologieal effects. Since the typical proton energy range in therapy is 70 to 250 MeV, measurements were exemplary performed at an initial proton beam energy of 175 MeV at the COoler SYnchrotron COSY of the Forschungszentrum Jülich. The beam was characterized by time of ftight measurements as well as by dosimetric and microdosimetric measurements in a water phantom. In the biological experiments cell survival was measured at various depths in water as a function of dose. This allows the determination of the RBE at different positions on the Bragg curve. The measurements were compared with theoretical calculations. Monte Carlo simulations with GEANT show good agreements with the dosimetric and microdosimetric quantities. The calculations of the RBE were performed with the microdosimetric model and the track structure model. The results showed deviations between measurements and both predictions, but a better statistic is necessary to give evidence. Nevertheless, the calculations give a better characterization of the RBE than the usual method in radiation therapy to assurne a constant enhancement in the area of the bragg peak. |