This title appears in the Scientific Report :
2019
Please use the identifier:
http://dx.doi.org/10.4155/fmc-2018-0336 in citations.
GABA A receptor family: overview on structural characterization
GABA A receptor family: overview on structural characterization
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This...
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Personal Name(s): | Amundarain, María Julia |
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Ribeiro, Rui Pedro / Costabel, Marcelo Daniel / Giorgetti, Alejandro (Corresponding author) | |
Contributing Institute: |
Computational Biomedicine; INM-9 Computational Biomedicine; IAS-5 |
Published in: | Future medicinal chemistry, 11 (2019) 3, S. 229 - 245 |
Imprint: |
London
Future Science
2019
|
PubMed ID: |
30801199 |
DOI: |
10.4155/fmc-2018-0336 |
Document Type: |
Journal Article |
Research Program: |
Theory, modelling and simulation |
Publikationsportal JuSER |
The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This deep characterization was hampered by the lack of experimental structural information for many years. Thus, computational techniques have been extensively combined with experimental data, in order to undertake the study of γ-aminobutyric acid type A receptors and their interaction with drugs. Here, we review the exciting journey made to assess the structures of these receptors and outline major outcomes. Finally, we discuss the brand new structure of the α1β2γ2 subtype and the amazing advances it brings to the field. |